| 胰岛素样生长因子在植入前胚胎细胞中的表达 |
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| 引用本文： | 张梅,郑英,谭丽,孙丽君,赵冬梅.胰岛素样生长因子在植入前胚胎细胞中的表达[J].河南医学研究,2003,12(4):307-308. |
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| 作者姓名： | 张梅 郑英 谭丽 孙丽君 赵冬梅 |
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| 作者单位： | 1. 平顶山第一人民医院妇产科,河南平顶山,467000
2. 郑州大学第二附属医院妇产科,河南郑州,450003 |
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| 摘 要： | 目的 :研究胰岛素样生长因子 1,2 (IGF 1,IGF 2 )在植入前胚胎的表达及其生物学意义。方法 :采用原位杂交法 ,检测人植入前胚胎细胞IGF 1,IGF 2mRNA的表达情况。结果 :IGF 1及IGF 2mRNA于不同阶段的植入前胚胎细胞中表达不同 ,各表达量有差异。结论 :不同阶段的植入前胚胎细胞分泌IGF 1、IGF 2 ,参与早期人类胚胎的生长、发育。
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| 关 键 词： | 胰岛素样生长因子 植入 胚胎 |
| 文章编号： | 1004-437X(2003)04-0307-02 |
| 修稿时间： | 2003年8月21日 |
Expression of insulin-like growth factors in human preimplantation embryos |
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| ZHANG Mei ,ZHENG Ying ,TAN Li ,SUN Li-jun ,ZHAO Dong-mei.Expression of insulin-like growth factors in human preimplantation embryos[J].Henan Medical Research,2003,12(4):307-308. |
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| Authors: | ZHANG Mei ZHENG Ying TAN Li SUN Li-jun ZHAO Dong-mei |
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| Affiliation: | ZHANG Mei 1,ZHENG Ying 2,TAN Li 2,SUN Li-jun 2,ZHAO Dong-mei 2 |
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| Abstract: | Objective: To investigate the expression of insulin-like growth factor-l , 2(IGF-l,IGF-2) in human preimplantation embryos and to explore the effects of insulin-like growth factors(IGFs) on human embryos growth and development. Methods: To detect the expression of IGF-1,2mRNA in human preimplantation embryos with in situ hybridization assays.Results: IGF-Ⅰ?mRNA and IGF-2 mRNA expression were found in some 2-cell to blastula stages embryos, there was difference in intensity of staining in different stages embryos. Conclusion: IGFs may act as an important role in human embryos growth and development though autocrine and endocrine ways. |
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| Keywords: | insulin-like growth factor preimplantation embryo |
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