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| 乳癖康合剂对乳腺增生病大鼠血清性激素及乳腺组织血管内皮生长因子、微血管密度表达的影响 | |
| 引用本文： | 李湘奇,宫少波,魏芳.乳癖康合剂对乳腺增生病大鼠血清性激素及乳腺组织血管内皮生长因子、微血管密度表达的影响[J].北京中医药大学学报(中医临床版),2005,12(5):1-3. |
| 作者姓名： | 李湘奇 宫少波 魏芳 |
| 作者单位： | 1. 山东中医药大学,山东,250014 2. 山东省中医药高等专科学校,山东,265200 3. 山东中医药大学附属医院,山东,250011 |
| 基金项目： | 山东省枣庄市科技局资助项目 |
| 摘 要： | 目的探讨乳癖康合剂(由柴胡、茯苓、三棱、莪术等组成)对乳腺增生病大鼠的治疗效果及作用机理.方法采用苯甲酸雌二醇联合黄体酮造模,用乳癖康合剂治疗30 d,观察大鼠乳腺增生的程度以及血清性激素水平的变化和其对乳腺组织血管内皮生长因子(VEGF)、微血管密度(MVD)表达的影响.结果乳癖康合剂能够降低乳腺增生病大鼠血清雌二醇(E2)、垂体促乳素(PRL)及促卵泡成熟激素(FSH)含量,升高孕激素(P)的含量.结论乳癖康合剂可通过调节乳腺增生病大鼠的性激素水平、影响VEGF的活性、抑制腺体新生血管的形成、改善腺体的微循环而逆转乳腺腺体的增生. |
| 关 键 词： | 乳癖康合剂 乳腺增生病 性激素 血管内皮生长因子 微血管密度 乳癖康合剂 乳腺增生病 大鼠 血清性激素 乳腺组织 血管内皮生长因子 微血管密度 表达 影响 Rats Tissue VEGF Expressions Hormones Serum Mixture 乳腺腺体 微循环 改善 新生血管 |
| 修稿时间： | 2005年5月16日 |
Influences of Rubikang Mixture on Serum Sex Hormones and Expressions of VEGF and MVD of Mammary Tissue in Rats with Cyclomastopathy |
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| Li Xiangqi,Gong Shaobo,Wei Fang.Influences of Rubikang Mixture on Serum Sex Hormones and Expressions of VEGF and MVD of Mammary Tissue in Rats with Cyclomastopathy[J].Journal of Beijing University of Traditional Chinese Medicine,2005,12(5):1-3. | |
| Authors: | Li Xiangqi Gong Shaobo Wei Fang |
| Abstract: | Objective To investigate the curative effect of Rubikang Mixture (consisting of Radix Bupleuri, Poria, Rhizoma Sparganii, Rhizoma Curcumae, and etc.) on the rats with cyclomastopathy and the mechanism. Method Benzestrofol and progesterone were injected to establish the model in rats, which was treated with Rubikang Mixture for 30 days. The mazoplasic degree and the influences of Rubikang Mixture on serum sex hormones and the expressions of VEGF and MVD of mammary tissue were observed. Result Rubikang Mixture decreased the contents of serum estradiol (E2), prolactin (PRL) and follicle-stimulating hormone (FSH) and increased the content of progestagen (P) in the rats with cyclomastopathy. Conclusion Through regulating the levels of sex hormones Rubikang Mixture could affect the activity of VEGF, inhibit the mammary neovascular formation, improve the microcirculation and reverse the mazoplasia. |
| Keywords: | Rubikang Mixture cyclomastopathy sex hormones vascular endothelial grown factor microvascular density |
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