紫斑牡丹籽饼粕单萜苷类成分的分离鉴定

目的:研究紫斑牡丹榨油后的籽饼粕单萜苷类化学成分的分离鉴定,探索油用牡丹籽油制备过程中的副产物——牡丹籽饼粕的研究开发价值。方法:采用硅胶、凝胶柱色谱以及半制备高效液相色谱等技术进行分离纯化,综合运用波谱学方法鉴定化合物的结构。结果:从油用牡丹籽饼粕中共分离的8个单萜苷类化合物,分别鉴定为β-gentiobiosyl-paeoniflorin(1)、白芍苷(2)、氧化白芍苷(3)、牡丹酮-1-O-β-D-吡喃葡萄糖苷(4)、白芍苷R1(5)、paeonifanin(6)、8-O-去苯甲酰白芍苷(7)、牡丹皮苷F(8)。结论:上述8个化合物均为首次从紫斑牡丹榨油后的牡丹籽饼粕中分离得到。结果表明油用牡丹籽饼粕中含有大量的单萜苷类化合物,具有重要的研究开发价值。

Isolation and Identification of Monoterpene Glucosides from Seed Cake of Paeonia rockii

Objective: To isolate and identify monoterpene glucosides from the seed cake of Paeonia rockii. Methods: Monoterpene glucosides were isolated and purified by successive column chromatographies on silica gel and Sephadex LH-20 and semi-preparative high performance liquid chromatography (semi-pre-HPLC). Spectroscopic methods were used to elucidate their structure. Results: Eight monoterpene glucosides were isolated from the seed cake of Paeonia rockii. They were identified as β-gentiobiosylpaeoniflorin (1), abiflofin (2), oxyalbiflorin (3), 1-O-β-D-glucopyransoyl-paeonisuffron (4), abiflofin R1 (5), paeonifanin (6), 8-O-debenzoyl-albiflorin (7), and mudanpioside F (8). Conclusions: All of these compounds were isolated from the seed cake of P. rockii for the first time in this study. These compounds and their derivatives were of significant interest for drug research and development. The study may provide important evidence supporting the exploitation of the seed cake of P. rockii.