| 胚鼠黑质细胞悬液移植于帕金森病模型鼠侧脑室的实验研究 |
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| 引用本文： | 余达经,刘云华,刘仁刚,周洁萍,朱长庚.胚鼠黑质细胞悬液移植于帕金森病模型鼠侧脑室的实验研究[J].华中科技大学学报(医学版),1992(2). |
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| 作者姓名： | 余达经 刘云华 刘仁刚 周洁萍 朱长庚 |
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| 作者单位： | 同济医科大学基础医学部解剖学教研室
(余达经，刘云华，刘仁刚，周洁萍)，同济医科大学基础医学部解剖学教研室(朱长庚) |
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| 摘 要： | 将胚鼠中脑腹侧组织制成细胞悬液移植于帕金森病(PD)模型鼠侧脑室,动态观察受体鼠在移植前后的行为变化。移植后16周应用诱发荧光及免疫细胞化学等方法,对移植物在受体鼠脑内的存活及生长情况进行了研究。结果,受体鼠旋转行为明显改善,侧脑室内可见黄绿色荧光细胞及酪氨酸羟化酶(TH)免疫反应阳性细胞,有的发出突起伸向室管膜及迁于尾核区.提示:移植的胚鼠黑质细胞生长良好,似作为触液神经元发挥其作用。
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| 关 键 词： | 胚鼠黑质细胞悬液 触液神经元 移植 脑室 帕金森病 |
An Experimental Study of the Transplantation of Fetal Nigral Cell Suspensions into the Lateral Ventricle of Parkinson's Disease Rats |
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| Yu Dajing,Liu Yunhua,Liu Rengang,Zhou Jieping,Zhu Changgeng.An Experimental Study of the Transplantation of Fetal Nigral Cell Suspensions into the Lateral Ventricle of Parkinson''''s Disease Rats[J].Journal of Huazhong University of Science and Technology(Health Sciences),1992(2). |
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| Authors: | Yu Dajing Liu Yunhua Liu Rengang Zhou Jieping Zhu Changgeng |
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| Affiliation: | Yu Dajing,Liu Yunhua,Liu Rengang,Zhou Jieping,Zhu ChanggengDepartment of Anatomy,Faculty of Basic Medical Sciences,Tongji Medical University,Wuhan |
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| Abstract: | The Nigral cell suspensions made from the ventral mesencephalon of fetal rats were transplanted into the lateral vetricle(LV) of Parkinson's disease (PD) rats. And the change in apomorphine-induced rotation behavior of the recipient was observed continually. Sixteen weeks after grafting using the methods of Faglu-Sucrose fluorescence histochemistry and tyrosine hydroxylase (TH) immunocytochemistry, survival and growth of grafts in the recipient brain were studied. The results showed that apomorphine-induced rotation behavior of the recipient rats shows a marked improvement; some groups of yellow-green -fluorescent and TH immunoreactive cells were found in the lateral ventricle of the host brain, some are dissociated, some have processes that extend to or contact ependyma, still some immigrate in caudate nucleus area adjoining the ependyma. The above-mentioned findings surggest that the fetal nigra dopamine (DA) cells implanted into the lateral ventricle grow very well and that their effects may be the same as those of the CSF-contacting neurons. |
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| Keywords: | fetal nigral cell suspensions CSF-contacting neurons transplantation ventricle Parkinson's disease (PD) |
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