Quantitative and comparative study of haematoporphyrin-derived photosensitizers on a murine tumour model |
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Authors: | Eberhard Unsöld Christian Ell Dieter Jocham Ronald Sroka Susanne Stocker |
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Affiliation: | (1) Zentrales Laserlaboratorium, Gesellschaft für Strahlen- und Umweltforschung mbH, D-8042 Neuherberg/München, Germany;(2) Medizinische Klinik I und Poliklinik, Universität Erlangen-Nürnberg, D-8520 Erlangen, Germany;(3) Urologische Klinik und Poliklinik, Universität München, D-8000 München, Germany |
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Abstract: | Eight commercially available HPD-photosensitizers intended for photodynamic therapy were tested in a murine tumour model with regard to their therapeutic efficacy. The regrowth delay of the fibrosarcoma SSK-2 on the mouse C3H, Neuherberg-line, was determined 3, 24, 48 and 72 h after injection of the drugs (dose: 9 mg kg–1 body weight). The corresponding pharmacodynamics, as measured by regrowth delay, were approximated by an exponential function and the characterizing coefficients derived. These coefficients served to quantify the photodynamic properties of the drugs.The pharmacodynamics of five substances were compared with those obtained fluorometrically. The latter showed shorter decay constants than the therapy-correlated substances which indicates different metabolic behaviour of the therapeutic and diagnostically useful fluorescent components of haematoporphyrin-derived photosensitizers. |
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Keywords: | Photodynamic therapy PDT Fluorescence Haematoporphyrin derivative HPD Diagnosis Murine tumour Laser Pharmacodynamic Pharmacokinetic Regrowth delay |
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