| 基于动态算法的序列分析 |
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| 引用本文： | 李誌,刘元宁,武泽旭,常亚萍,何飞,徐宝林,张浩.基于动态算法的序列分析[J].长春邮电学院学报,2010(1):41-46. |
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| 作者姓名： | 李誌 刘元宁 武泽旭 常亚萍 何飞 徐宝林 张浩 |
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| 作者单位： | [1]吉林大学计算机科学与技术学院,长春130012 [2]吉林大学畜牧兽医学院,长春130062 [3]四川大学电气信息学院,成都610065 |
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| 基金项目： | 国家自然科学基金资助项目（60673099;60873146;60971089） |
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| 摘 要： | 为了获得2009年新型甲型H1N1流感病毒与2008流感病毒的基因序列及氨基酸序列的一致性,以便对一个基因家族的生物学特征有一个简明扼要的了解,针对目前流行的新型甲型H1N1流感病毒的基因序列及其所编码的氨基酸序列,采用动态规划算法对其一级序列进行序列相似度分析,获得了2009年新型甲型H1N1流感病毒的NA和M基因片段以及2008年猪源性甲型H1N1流感病毒的相应基因片段同源性高、在有些位点发生了基因突变增添和突变缺失等重要基因信息。为此次新型甲型H1N1流感病毒的研究提供了依据。
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| 关 键 词： | 生物信息学 序列比对 相似性分析 |
Sequence Analysis Based on Dynamic Algorithm |
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| LI Zhia,LIU Yuan-ninga,WU Ze-xu,CHANG Ya-pinga,HE Feia,XU Bao-linb,ZHANG Hao.Sequence Analysis Based on Dynamic Algorithm[J].Journal of Changchun Post and Telecommunication Institute,2010(1):41-46. |
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| Authors: | LI Zhia LIU Yuan-ninga WU Ze-xu CHANG Ya-pinga HE Feia XU Bao-linb ZHANG Hao |
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| Affiliation: | 1a. College of Computer Science and Technology,Jilin University,Changchun 130012,China; 1b. College of Animal Science and Veterinary Medicine,Jilin University,Changchun 130062,China; 2. College of Electrical Engineering and Information,Sichuan University,Chengdu 610065,China) |
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| Abstract: | Sequence alignment is the basis of sequence analysis,which describes the similarity of sequences in a set to understand the biological characteristics of a gene family concisely. The dynamic programming algorithm is adopted to analyze the similarity of the sequence of current-new H1N1 influenza virus gene sequences and their encoded amino acid sequences. Some important genetic information is obtained,such as high homologous be-tween NA and M gene fragments of 2009 new H1N1 influenza virus and corresponding gene fragments of 2008 swine H1N1 influenza,gene mutation in some sites plus-deletion mutation. These results provide the basis for the further study of this new H1N1 influenza virus. |
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| Keywords: | bioinformatics sequence comparison similarity analysis |
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