食源性病原菌激发固有免疫细胞胞外诱捕网的研究进展

固有免疫细胞在外源物质刺激后向细胞胞外环境释放由染色质DNA和多种胞内颗粒蛋白组成的纤维样网状物质，称为胞外诱捕网（extracellular traps，ETs）。ETs是一种新型的宿主防御机制，能够捕获或杀灭病原菌，有效控制病原菌的扩散，从而使机体免受感染。大肠杆菌、沙门菌等食源性人兽共患病病原体引发的疾病是全球广泛关注的公共卫生问题。本文就食源性病原菌激发固有免疫细胞ETs的形成、ETs的生物学活性以及细菌部分蛋白对ETs形成的影响等研究进展进行综述，以期为食源性疾病的防控提供相关理论参考。

Research Progress on Extracellular Traps of Innate Immune Cells Stimulated by Foodborne Pathogens

Innate immune cells release fibrous net substances which are composed of chromatin DNA and various intracellular protein components to the extracellular environment after being stimulated by exogenous substances. Those substances are called extracellular traps (ETs). ETs are new types of host defense mechanism that can capture or kill pathogens, control the spread of pathogens, and protect the body from infection. Diseases caused by foodborne zoonotic pathogens, such as Escherichia coli and Salmonella, are public health issues of widespread concern worldwide. This article reviews the research progress of the formation of ETs stimulated by foodborne pathogens, the biological activity of ETs, and the influence of some bacterial proteins on the formation of ETs. This article is intended to provide theoretical reference for the prevention and control of foodborne diseases.