Regulating the acrosome reaction |
| |
| Authors: | Florman Harvey M Jungnickel Melissa K Sutton Keith A |
| |
| Affiliation: | Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA. harvey.florman@umassmed.edu |
| |
| Abstract: | The acrosome reaction is a secretory event that must be completed by the sperm of many animal species prior to fusion with eggs. In mammals, exocytosis in triggered by ZP3, a glycoprotein component of the egg pellucida, following gamete contact. ZP3 promotes a sustained influx of Ca2+ into sperm that is necessary for the acrosome reaction. Here, we discuss the mechanism by which ZP3 generates Ca2+ entry, as well as the upstream events leading to this influx and downstream processes that couple it with exocytosis. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
