| 2,6-二氟苯腈的合成 |
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| 引用本文： | 邱滔,范正明,严生虎.2,6-二氟苯腈的合成[J].精细化工,2000,17(1):52-54. |
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| 作者姓名： | 邱滔 范正明 严生虎 |
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| 作者单位： | 江苏石油化工学院,精细化工研究所,江苏,常州,213016 |
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| 摘 要： | 以２，６ 二氯苯腈（ＤＣＢＮ）和氟化钾为原料，采用非极性溶剂环丁砜为反应介质，经氟化合成了２，６ 二氟苯腈（ＤＦＢＮ）。对影响产率的诸因素进行了考察，其最佳工艺条件是：ｎ （ＤＣＢＮ）∶ｎ（ＫＦ）∶ｎ（季铵盐）∶ｎ（阻聚剂）＝１∶２－６∶０－０２∶０－０４，反应温度为１７０～１７５ ℃（ 第一步）和２２０ ℃（第二步） ，反应时间为１－５ ｈ（第一步）和３－５ ｈ（第二步），产品的收率可达９０％ 左右，纯度≥９８％ 。
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| 关 键 词： | 2 6-二氟苯腈 2 6-二氯苯腈 氟化钾 氟化 |
| 文章编号： | 1003-5214(2000)01-0052-03 |
Synthesis of 2,6-Difluorobenzonitrile |
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| QIU Tao,FAN Zheng-ming,YAN Sheng-hu.Synthesis of 2,6-Difluorobenzonitrile[J].Fine Chemicals,2000,17(1):52-54. |
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| Authors: | QIU Tao FAN Zheng-ming YAN Sheng-hu |
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| Abstract: | Difluorobenzonitrile(DFBN) was prepared by 2,6 dichlorobenzonitrile(DCBN) and KF using sulfolane as a non polar solvent.Factors influencing the yield were discussed.The optimum reaction conditions were as follow: n(DCBN)∶ n(KF)∶ n(quaternaries)∶ n(inhibitor) = 1∶2 6∶0 02∶0 04 ,reaction temperature 170～175 ℃(in the first step) and 230 ℃ (in the second step) and reaction time 1 5 h (in the first step) and 3 5 h (in the second step). The yield of the product reached 90% and the purity was 98%. |
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| Keywords: | difluorobenzonitrile 2 6 dichlorobenzonitrile potassium fluoride fluorination |
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