| 非清髓异基因造血干细胞移植治疗急性白血病的临床研究 |
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| 引用本文： | 王丹红,艾辉胜,余长林,乔建辉,郭梅,孙万军,姚波,张石.非清髓异基因造血干细胞移植治疗急性白血病的临床研究[J].解放军医学杂志,2001,26(1):8-9. |
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| 作者姓名： | 王丹红 艾辉胜 余长林 乔建辉 郭梅 孙万军 姚波 张石 |
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| 作者单位： | 军事医学科学院附属医院 |
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| 摘 要： | 采用非清髓预处理（环胞霉素A、环磷酰胺、阿糖胞苷及CD3单克隆抗体或抗淋巴细胞球蛋白）的异基因外周造血干细胞移植治疗急性白血病5例。5例病人均顺利度过造血抑制期并移植成功。2例例经嵌合性植入转为完全植入，另3例为嵌合性植入。5例中2例发生Ⅱ～Ⅲ度GVHD，经治疗后治愈。5例中4例仍无病存活。结果表明，非清髓异基因造血干细胞移植简便安全，并发症少，疗效较好，为急性白血病的治疗提供了新手段。
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| 关 键 词： | 预处理 非清髓异基因造血干细胞移植 急性白血病 NAST |
| 修稿时间： | 2000年12月14 |
NONMYELOABLATIVE ALLOGENIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR THE TREATMENT OF ACUTE LEUKAEMIA |
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| Wang Danhong,Ai Huisheng,Yu Changlin et al.NONMYELOABLATIVE ALLOGENIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR THE TREATMENT OF ACUTE LEUKAEMIA[J].Medical Journal of Chinese People's Liberation Army,2001,26(1):8-9. |
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| Authors: | Wang Danhong Ai Huisheng Yu Changlin |
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| Affiliation: | Wang Danhong,Ai Huisheng,Yu Changlin et al .Attached Hospital,Academy of Military Medical Science,Beijing 100039 |
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| Abstract: | Five cases of acute leukaemia patients with received nonmyeloablative allogeneic peripheral blood stem cells transplantation(NAPBSCT) from HLA identical siblings using a nonmyeloablative conditioning regimen.The engrafted donor cell were identified by means of conventional chromosome analysis and STR PCR analysis. The results showed five cases had engraftments of donor cell, two with donor chimerism,three mixed chimerism . Two of five cases developed aGVHD. Four of five cases survived free of the disease. These findings indicated NAPBSCT is much safer and more effective approach in the management of acute leukaemia. |
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| Keywords: | nonmyeloablative conditioning regimen allogenic peripheral blood stem cells transplantation acute leukaemia |
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