生长抑素联合泮托拉唑治疗急性上消化道出血的临床价值探讨

目的探讨生长抑素联合泮托拉唑治疗急性上消化道出血的临床效果。方法将我科2011年3月至2013年9月收治的88例急性上消化道出血患者按不同治疗方法分为对照组（40例，常规治疗基础上加用泮托拉唑）和试验组（48例，泮托拉唑联合生长抑素治疗），对两组患者治疗效果进行综合比较。结果（1）试验组治疗总有效率91．67％（44／48）明显高于对照组75．00％（30／40）（P〈0．05）；（2）试验组PLT、PCT分别为（265．0±11．3）×10^9／L、（25．5±5．2）％，对照组为（232．5±10．9）×10^9／L、（21．4±5．1）％，组间比较有统计学差异（P〈0．01）；（3）试验组止血成功时间及住院时间分别为（30．3±10．2）h、（7．0±1．4）d，对照组为（46．5±10．9）h、（11．2±2．6）d，组间比较有统计学差异（P〈0．01）。结论生长抑素联合泮托拉唑治疗急性上消化道出血效果显著，值得临床推广应用。

Study on clinical value of somatostatin combined with pantoprazole in the treatment of acute upper gastrointestinal hemorrhage

Objective To investigate the clinical effect of somatostatin combined with pantoprazole in the treatment of acute upper gastrointestinal hemorrhage. Methods 88 cases of acute upper gastrointestinal hemorrhage in our hospital from March 2011 to September 2013 were divided into control group （40 cases, given pantoprazole on the basis of conventional） and experimental group （48 cases, given somatostatin combined with pantoprazole）, the efficacy of two groups were compared. Results ① The effective-rate of experimental group （91.67%） was higher than that of control group （75.00%） （P〈 0.05）; ② After 3 days of treatment, PLT, PCT of experimental group were （265.0 ± 11.3） × 10^9/L, （25.5 ± 5.2）%, those were （232.5 ± 10.9） × 10^9/L, （21.4 ± 5.1）% in control group, there were statistically significant differences between two groups （P 〈 0.01）; ③ The time of successful hemostasis and hospitalization of experimental group were （30.3 ± 10.2） h and （7.0 ± 1.4） d, those were （46.5 ± 10.9）h and （11.2 ± 2.6） d in control group, there were statistically significant differences between two groups （P 〈 0.01）. Conclusion Somatostatin combined with pantoprazole has significant effect in treating acute upper gastrointestinal hemorrhage, which is worthy of clinical promotion.