老年男性血清脂联素与骨密度的关系

目的：研究老年男性血清脂联素与骨密度和骨转化指标之间的关系。方法：对165例男性老年患者采用双能量X线吸收测量仪测定骨密度、肌肉及脂肪量,同时测定患者血清脂联素、骨碱性磷酸酶、甲状旁腺素、25羟维生素D和I型胶原β羧基端肽水平。结果：165例年龄超过58岁男性患者（平均年龄69.4±6.4岁,体重指数24.9±3.1 kg/m2）,脂联素与股骨颈骨密度相关系数为-0.31（P〈0.05）、与全髋骨密度相关系数为-0.23（P〈0.05）,年龄、BMI和脂肪量校正后,脂联素仅与股骨颈骨密度有显著相关（r=-0.25,P〈0.05）;脂联素与骨碱性磷酸酶正相关（r=0.28,P〈0.01）,混杂因素校正后,相关仍具有显著性（r=0.19,P〈0.05）;脂联素与I型胶原β羧基端肽呈正相关（r=0.15,P〈0.05）。结论：老年男性血清脂联素与股骨颈骨密度和骨ALP密切相关。

The Relationship of Serum Adiponectin with Bone Mineral Density in Elderly Men

Objective： To investigate the relationship of adiponectin with bone mineral density （BMD） and bone turnover markers in elderly men. Methods： BMD body composition （fat mass and lean mass） were detected by a dual-energy X-ray adsorptiometry （DXA） device in 165 elderly men. And serum levels of adiponectin, bone alkaline phosphatase （ALP）, intact parathyroid hormone （PTH）, 25-hydroxyvitamin D （25 OH]D）, and the carboxy-terminal telopeptide of type I collagen （3CTX） were evaluated. Results： In 165 men aged 58 years and older （mean age 69.4 ± 6.4 years, mean body mass index IBM1] 24.9 ±3.1 kg/m2）. Adiponectin showed significant correlations with BMD at the femoral neck （r = -0.31, P〈0.01）and total hip （r = -0.23, P〈0.05）. However, after adjusting for age, BMI, and fat mass, the correlation remained significant only for femoral neck BMD （r = -0.25, P〈0.05 ）. Adiponectin showed a positive association with bone ALP （r = 0.28, P〈0.01）; The relationship between adiponectin and bone ALP remained significant after adjusting for confounding variables （r = 0.19, P〈0.05）. Adiponectin showed a positive association with 13CTX （r = 0.15, P〈0.05 ）. Conclusion： In elderly men serum adiponectin was significantly associated with femoral neck BMD and bone ALP.