T型微通道内丙酸倍氯米松纳米颗粒的制备

引言干粉吸入剂是将一种或多种药物制成一定范围的微小颗粒,经特殊的给药装置使药物以粉雾状进入呼吸道和肺部,发挥局部或全身的作用.影响吸人的因素主要有粒径大小、形态、分散性和吸湿性等特性,其中药物的粒径大小和分布是影响DPI肺部沉积率的重要因素[1-2].因此,药物纳米化是干粉吸入剂取得成功的一大关键.目前,多采用的药物纳米化技术为机械粉碎(如球磨、气流粉碎),制备的产品粒度分布宽、能耗大、效率低、易使热不稳定药物的结构破坏或降解等[3].而相对于传统的机械纳米化过程,液相沉淀法显示了更好的可控性,并且由于其操作简单、弹性大、设备投资小,而成为制备纳米药物颗粒的主要方法之一[4].

Preparation of beclomethasone dipropionate nanoparticles in T-junction microreactor

As model drug,beclomethasone dipropionate(BDP)nanoparticles were prepared by using the antisolvent precipitation method in a T-junction microchannel. The influence of surfactant on particle morphology,as well as the influences of surfactant concentration,BDP solution flow rate,antisolvent flow rate,BDP solution concentration and precipitation temperature on particle size were explored. The results indicated that the morphology of BDP was spherical with the addition of surfactant(HPMC).Besides,the particle size decreased with decreasing BDP solution flow rate,increasing antisolvent flow rate and decreasing precipitation temperature. However,with the increase of BDP concentration,particle size reached a minimum. BDP nanoparticles with an average size of 200—260 nm and narrow size distribution could be prepared under the following conditions: BDP solution flow rate of 4 ml·min^-1,