| 重要产毒镰刀菌合成白僵菌素和恩镰孢菌素研究进展 |
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| 引用本文： | 韩小敏,李凤琴,徐文静,王美美,鲜婷婷.重要产毒镰刀菌合成白僵菌素和恩镰孢菌素研究进展[J].中国食品卫生杂志,2019,31(1):89-93. |
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| 作者姓名： | 韩小敏 李凤琴 徐文静 王美美 鲜婷婷 |
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| 作者单位： | 国家食品安全风险评估中心 国家卫生健康委员会食品安全风险评估重点实验室,北京 100021,国家食品安全风险评估中心 国家卫生健康委员会食品安全风险评估重点实验室,北京 100021,国家食品安全风险评估中心 国家卫生健康委员会食品安全风险评估重点实验室,北京 100021,国家食品安全风险评估中心 国家卫生健康委员会食品安全风险评估重点实验室,北京 100021,国家食品安全风险评估中心 国家卫生健康委员会食品安全风险评估重点实验室,北京 100021 |
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| 基金项目： | 国家重点研发计划生物安全关键技术研发重点专项(2017YFC1200901) |
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| 摘 要： | 白僵菌素(beauvericin,BEA)和恩镰孢菌素(enniatins,ENNs)是由镰刀菌属的多种真菌产生的六酯肽类真菌毒素,该类毒素对上皮细胞、免疫细胞、卵巢细胞等具有很强的毒性作用。本文主要针对能产生BEA和ENNs的重要产毒镰刀菌的形态学特征、分子遗传学特征以及影响BEA和ENNs产生的环境条件如温度、底物等因素进行概述。重点阐述了产毒镰刀菌在两类毒素合成酶的基因水平和氨基酸水平的差异及影响产毒等主要因素,为BEA和ENNs及其产毒镰刀菌的预防和控制提供理论依据。
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| 关 键 词： | 镰刀菌 白僵菌素 恩镰孢菌素 六酯肽类真菌毒素 产毒特征 |
| 收稿时间： | 2018/12/29 0:00:00 |
Progress on biosynthesis of beauvericin and enniatins for important toxin-producing Fusarium species |
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| HAN Xiaomin,LI Fengqin,XU Wenjing,WANG Meimei and XIAN Tingting.Progress on biosynthesis of beauvericin and enniatins for important toxin-producing Fusarium species[J].Chinese Journal of Food Hygiene,2019,31(1):89-93. |
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| Authors: | HAN Xiaomin LI Fengqin XU Wenjing WANG Meimei and XIAN Tingting |
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| Affiliation: | NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment,Beijing 100021,China,NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment,Beijing 100021,China,NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment,Beijing 100021,China,NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment,Beijing 100021,China and NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment,Beijing 100021,China |
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| Abstract: | Beauvericin (BEA) and enniatins (ENNs) are a group of hexadepsipeptides mycotoxins produced by several species of Fusarium, which show strong toxic effects on epithelial cells, immune cells and ovarian cells. The morphology and the molecular genetic characteristics of toxin-producing Fusarium species are introduced, as well as the environmental conditions, such as temperature and substrate, which can influence BEA and ENNs production. The differences in genetic level and the amino acid level about synthetase of two types of mycotoxins, and their influencing factors about mycotoxin-producing Fusarium species are expounded emphatically. It will provide a theoretical basis for the prevention and control of two types of mycotoxin and mycotoxin-producing Fusarium species. |
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| Keywords: | Fusarium beauvericin enniatins hexadepsipeptides mycotoxins toxin-producing characteristics |
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