| 微泵耳蜗灌注碱性成纤维生长因子对庆大霉素致聋豚鼠的作用 |
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| 引用本文： | 叶放蕾,董明敏.微泵耳蜗灌注碱性成纤维生长因子对庆大霉素致聋豚鼠的作用[J].郑州大学学报(医学版),2003,38(3):354-356. |
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| 作者姓名： | 叶放蕾 董明敏 |
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| 作者单位： | 郑州大学第一附属医院耳鼻咽喉科,郑州,450052 |
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| 基金项目： | 河南省科技攻关资助项目 0 2 2 463 0 0 14 |
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| 摘 要： | 目的 :应用微量渗透泵 (MOP)向豚鼠耳蜗灌注碱性成纤维生长因子 (bFGF) ,观察其对庆大霉素中毒所致耳聋的保护作用。方法 :10只豚鼠分成庆大霉素致耳聋组及正常组 ,于 2组豚鼠右耳耳蜗植入MOP灌注bFGF ,分别于灌注前 ,灌注后 1周、2周测ABR阈值 ,扫描电镜观察耳蜗组织形态。结果 :耳聋组在灌注bFGF后 1周、2周ABR阈值较灌注前降低 (P <0 .0 5 ) ,耳蜗毛细胞形态得以恢复 ;正常组ABR阈值及形态均无明显改变。结论 :MOP持续恒速耳蜗灌注bFGF对耳蜗中毒的毛细胞有修复作用 ,对正常耳蜗功能和形态无影响
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| 关 键 词： | 微泵 耳蜗灌注 碱性成纤维生长因子 庆大霉素 耳聋 防治 |
| 修稿时间： | 2002年11月27 |
Protective effects of bFGF perfused to cochlea by MOP on the hearing loss induced by gentamicin for guinea pigs |
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| YE Fanglei,DONG Mingmin.Protective effects of bFGF perfused to cochlea by MOP on the hearing loss induced by gentamicin for guinea pigs[J].Journal of Zhengzhou University: Med Sci,2003,38(3):354-356. |
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| Authors: | YE Fanglei DONG Mingmin |
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| Affiliation: | YE Fanglei,DONG Mingmin Department of Otolaryngology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 |
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| Abstract: | Aim:To investigate the protective effects of bFGF perfused to cochlea by MOP on the hearing loss induced by gentamicin. Methods:Ten guinea pigs were randomly allocated into 2 groups:the deafness group and the normal control group. bFGF was perfused to the cochlea by MOP.ABR and the morphological features of cochlea before perfusion,1 and 2 week after perfusion were observed.Results:The auditory threshold of ABR decreased in the deafness group at 1 and 2 weeks after perfusion( P <0.05)and the morphological lesions of hair cell alleviated compared to those before perfusion.No sigmficant changes were fourd for normal controls.Conclusion:A continual perfusion of bFGF to cochlea by MOP can repair the hair cell injury by gentamicin and have no effects on normal cochlea. |
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| Keywords: | cochlea bFGF guinea pig hearing loss gentamicin |
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