| 新型冠状病毒感染诱导的机体自身免疫 |
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| 引用本文： | 陈奕孛,陈梦棣,苗根,戚中田,丁翠玲.新型冠状病毒感染诱导的机体自身免疫[J].国际生物制品学杂志,2023,46(1):13-18. |
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| 作者姓名： | 陈奕孛 陈梦棣 苗根 戚中田 丁翠玲 |
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| 作者单位： | 1海军军医大学海军医学系生物医学防护教研室，上海 200433；2海军军医大学基础医学院，上海 200433 |
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| 摘 要： | 新型冠状病毒（severe acute respiratory syndrome coronavirus 2，SARS-CoV-2）感染不仅严重影响人体免疫，而且可能诱发易感人群的自身免疫病。此文对SARS-CoV-2感染者体内产生的5大类自身抗体以及这些自身抗体可能导致的自身免疫病、患者自身免疫系统过度激活的相关研究进展，以及其诱导机体自身免疫的可能机制进行综述，以期为SARS-CoV-2相关的自身免疫性损伤与疾病的研究提供理论基础。
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| 关 键 词： | 新型冠状病毒 自身抗体 自身免疫病 |
Autoimmunity induced by SARS-CoV-2 infection |
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| Affiliation: | 1Department of Medical Biodefence, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China；2School of Basic Medical Sciences, Naval Medical University, Shanghai 200433, China |
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| Abstract: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection not only seriously affects human immunity, but also may induce autoimmune diseases in genetically susceptible people. The research progresses of five major types of autoantibodies produced in SARS-CoV-2 infected patients, the autoimmune diseases that may be caused by autoantibodies, the excessive activation of the patients’ autoimmune system, and the possible mechanisms that autoimmunity induced by SARS-CoV-2 infection were summarized in this review, which aims to provide a theoretical basis for the study of SARS-CoV-2-related autoimmune injury and diseases. |
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| Keywords: | Severe acute respiratory syndrome coronavirus 2 Autoantibody Autoimmune diseases |
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