冠心病心房颤动病人血浆D-D、Fg水平与左心房大小的相关性分析

目的：探讨冠心病心房颤动(房颤)病人血浆D-二聚体(D-D)、纤维蛋白原(Fg)水平与左心房大小的相关性。方法：选取119例单纯冠心病、108例冠心病房颤病人和105名健康人，分别记为冠心病组、冠心病房颤组和健康组。检测对比3组血浆D-D、Fg水平与左心房大小。采用Pearson法分析在冠心病房颤组血浆D-D、Fg水平与左心房大小的相关性。结果：冠心病组、冠心病房颤组血浆D-D、Fg水平与左心房收缩末期直径(LAD)均大于健康组，且冠心病房颤组均大于冠心病组(P<0.01);急性心肌梗死血浆D-D、Fg水平与LAD均大于冠心病心绞痛、缺血性心肌病(P<0.01),冠心病心绞痛均大于缺血性心肌病；永久性房颤血浆D-D、Fg水平与LAD均大于阵发性和持续性房颤，持续性房颤血浆D-D、Fg水平与LAD均大于阵发性房颤(P<0.01)。冠心病房颤组血浆D-D、Fg水平与LAD均呈正相关关系(r=0.603、0.612,P<0.05和<0.01)。结论：冠心病房颤病人血浆D-D、Fg水平升高，且与左心房大小呈正相关。

Correlation between plasma D-dimer,fibrinogen levels and left atrial dimension in patients with coronary heart disease and atrial fibrillation

ObjectiveTo explore the correlation between plasma D-dimer (D-D), fibrinogen (Fg) levels and left atrial dimension in patients with coronary heart disease and atrial fibrillation.MethodsA total of 332 patients were enrolled and divided into coronary heart disease group(n=119), coronary heart disease atrial fibrillation group(n=108) and healthy group(n=105) according to the diseases suffered.Plasma D-D, Fg levels and left atrial dimension were measured and compared of all patients, Pearson method was used to analyze the correlation between the plasma D-D, Fg levels and left atrial dimension.ResultsThe plasma D-D, Fg levels and left atrial end systolic diameter (LAD) in coronary heart disease group and coronary heart disease atrial fibrillation group were higher than those in healthy group, and those in coronary heart disease atrial fibrillation group were higher than those in coronary heart disease group(P < 0.01).The plasma D-D, Fg levels and LAD in acute myocardial infarction were higher than those in coronary heart disease angina pectoris and ischemic cardiomyopathy, and those of angina pectoris of coronary heart disease were higher than ischemic cardiomyopathy(P < 0.01).The plasma levels of D-D, Fg and LAD in permanent atrial fibrillation were higher than those in paroxysmal and persistent atrial fibrillation, and the plasma levels of D-D, Fg and LAD in persistent atrial fibrillation were higher than those in paroxysmal atrial fibrillation (P < 0.01).The plasma D-D and Fg levels were positively correlated with LAD in patients with coronary heart disease and atrial fibrillation (r=0.603, 0.612, P < 0.05 and P < 0.01).ConclusionsThe plasma D-D and Fg levels in patients with coronary heart disease and atrial fibrillation are increased, which are positively correlated with left atrial dimension.