血清降钙素原和T细胞亚群对脑出血患者感染的预测效果

目的探讨血清降钙素原(PCT)和T细胞亚群对脑出血患者感染的预测效果。方法选取脑出血患者80例,依据感染发生情况分为感染组和未感染组,比较2组患者的血清PCT、T细胞亚群。对入组患者的临床资料进行多因素Logistic回归分析,绘制ROC曲线评估血清PCT和T细胞亚群对脑出血患者感染的预测效果。结果感染组患者的血清PCT、CD_8~+显著高于未感染组,CD_3~+、CD_4~+、CD_4~+/CD_8~+显著低于未感染组(P0.05)。入院时NIHSS评分、血清PCT、CD_3~+、CD_4~+/CD_8~+是影响脑出血患者感染的独立危险因素(P0.05)。血清PCT、CD_4~+/CD_8~+曲线下面积分别为0.833、0.869,对脑出血患者感染具有良好的预测效果(P0.05)。结论血清PCT和T细胞亚群是影响脑出血患者感染的独立危险因素。

Predictive effect of serum PCT and T cell subsets on treatment of patients with intra-cerebral hemorrhage

Objective To investigate the predictive effect of serum PCT and T cell subsets on treatment of patients with cerebral hemorrhage infection.Methods A total of 80 patients with cerebral hemorrhage were divided into infection group and non-infection group.Serum PCT and T cell subsets were compared.Clinical data of patients were analyzed by multivariate Logistic regression analysis,and ROC curve was used to evaluate the effect of PCT and T cell subsets on cerebral hemorrhage infection.Results Serum PCT and CD8+ in the infection group were significantly higher than non-infected group,while CD3+,CD4+,CD4+/CD8+ were significantly lower than the non-infection group (P<0.05).The NIHSS score on admission,serum PCT,CD3+,CD4+/CD8+ were independent risk factors for infection in patients with intra-cerebral hemorrhage (P<0.05).The ROC curves of serum PCT,CD4+/CD8+ were 0.833,0.869,which showed good predictive effect for cerebral hemorrhage infection (P<0.05).Conclusion Serum PCT and T cell subsets are independent risk factors for infection in patients with intra-cerebral hemorrhage.