2型糖尿病患者角膜知觉减退的研究进展

角膜知觉减退是由于多种原因造成的神经传导功能障碍。尽管角膜知觉减退是否是糖尿病的眼部症状还存在争议,但是最近有研究表明,它与糖尿病病程、血糖控制情况和糖尿病神经病变都存在相关性。近几年,角膜知觉减退作为糖尿病周围神经病变的一个监测指标成为研究热点之一。其机制可能是由于神经细胞内糖代谢产物累积、神经纤维数量减少和长度缩短、免疫机制所导致。我们现就角膜知觉减退与糖尿病的国内外研究进展做一综述。

A review of corneal sensitivity reduction in diabetic patients

Corneal sensitivity reduction is a common nerve conduction dysfunction due to a variety of causes. Although whether corneal sensitivity reduction is a symptom of diabetes is still controversial, it has strong correlation with the duration of diabetes,glycemic control and also diabetic peripheral neuropathy. In recent years, the corneal sensation as a monitoring indicator of diabetic peripheral neuropathy has been extensively researched. The mechanism may be the sugar metabolites accumulation in the nerve cells, the reduced number and the shortened length of nerve fibers, or immune mechanisms.