| Lupeol及其衍生/修饰物对肝癌细胞增殖影响的研究 |
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| 引用本文： | 刘芬,何艳,李云森,朱永明,刘海燕.Lupeol及其衍生/修饰物对肝癌细胞增殖影响的研究[J].现代肿瘤医学,2011,19(12):2393-2396. |
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| 作者姓名： | 刘芬 何艳 李云森 朱永明 刘海燕 |
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| 作者单位： | 1. 苏州大学生物医学研究院肿瘤细胞与分子免疫实验室,江苏,苏州,215123
2. 苏州大学医学部药学院,江苏,苏州,215123 |
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| 基金项目： | 苏州市重点实验室资助项目 |
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| 摘 要： | 目的:探讨lupeol及其结构改造后衍生/修饰物对肝癌细胞HepG2和SMMC7721细胞增殖的作用。方法:对lupeol进行化学结构修饰,然后应用MTT方法检测lupeol及其衍生/修饰物对HepG2和SMMC7721细胞增殖的作用。结果:MTT数据显示,lupeol及其衍生/修饰物均能抑制HepG2和SMMC7721细胞增殖,并且具有浓度依赖性。Lupeol、H1、T1和T2的IC50分别为40μmol/L-50μmol/L、约120μmol/L、约50μmol/L和70μmol/L-80μmol/L。结论:lupeol结构改造后,并没有提高其对肝细胞肝癌细胞增殖的抑制作用。
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| 关 键 词： | 肝细胞肝癌细胞系 lupeol 细胞增殖 |
Effects of Lupeol and its modified compounds on cell proliferation of hepatocellular carcinoma cell lines |
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| LIU Fen,HE Yan,LI Yunsen,ZHU Yongming,LIU Haiyan.Effects of Lupeol and its modified compounds on cell proliferation of hepatocellular carcinoma cell lines[J].Journal of Modern Oncology,2011,19(12):2393-2396. |
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| Authors: | LIU Fen HE Yan LI Yunsen ZHU Yongming LIU Haiyan |
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| Affiliation: | LIU Fen1,HE Yan1,LI Yunsen1,ZHU Yongming2,LIU Haiyan1 1 Department of Laboratory of Cellular and Molecular Tumor Immunology,Institute of Biology and Medical Sciences,Soochow University,Jiangsu Suzhou 215123,China,2School of Pharmacy,Medical College of Soochow University |
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| Abstract: | Objective:To investigate the effects of lupeol and its modified compounds on proliferation of hepatocellular carcinoma cells HepG2 and SMMC7721.Methods: The structure of lupeol was modified.Then cell viability of HepG2 and SMMC7721 was measured by MTT assay after treatment with increasing concentration of lupeol or its modified compounds.Results: MTT results showed that lupeol and its modified compounds inhibited the proliferation of HepG2 and SMMC7721 cells in a concentration dependent manner.IC50 of lupeo... |
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| Keywords: | HCC cell line lupeol cell proliferation |
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