无梗五加果化学成分的分离与鉴定

目的:对五加科五加属植物无梗五加Acanthopanax sessiliflorus果的化学成分进行分离与鉴定.方法:采用硅胶柱色谱,Sephadex LH-20柱色谱等方法对化学成分进行分离及纯化,根据化合物理化性质及波谱数据鉴定其结构.结果:分离得到9个化合物,oleanolic acid-3-O-6'-O-methyl-β-D-glucumnopyranoside(1),22-α-hydroxychiisanogenin(2),齐墩果酸-3-o-β-D-葡萄糖醛酸苷(momordin Ib 3),齐墩果酸-3-O-β-D-葡萄糖苷(oleanolic acid-3-O-β-D-glucopyranoside 4),齐墩果酸(oleanolic acid 5),ehiisanogenin(6),(-)-芝麻脂素(-)-sesamin 7],胡萝卜苷(daucosterol 8),β-谷甾醇(β-sitosterol 9).结论:化合物1是首次从五加属植物中分离得到,化合物2～5是首次从该植物中分离得到.

Isolation and identification of chemical constituents of fruits of Acanthopanax sessiliflorus

Objective: To isolate and elucidate the chemical constituents of the fruits of Acanthopanax sessiliflorus.  Method: Isolation and purification were carried out on the column chromatography of silica gel and Sephadex LH 20. Their structures were elucidated on basis of physicochemical properties and spectral data.  Result: Nine compounds were isolated and identified as oleanolic acid 3 O 6′ O methyl β D glucuronopyranoside (1), 22 α hydroxychiisanogenin (2), oleanolic acid 3 O β D glucuronopyranoside (3), oleanolic acid 3 O β D glucopyranoside (4), oleanolic acid (5), chiisanogenin (6), (-) sesamin (7), daucosterol (8), β sitosterol (9).  Conclusion: Compound 1 is obtained from the genus Acanthopanax genus for the first time. Compounds 2 5 are isolated from this plant for the first time.