凝集素介导的生物黏附微粒制剂研发趋势

阐述了第二代生物黏附微粒制剂的概念及黏附机制，介绍了影响凝集素黏附性能的因素和凝集素的类型，并对该系统的应用及发展趋势进行了概述。生物黏附释药系统作为一种新颖的药物释放系统，以特有的靶向性，缓、控释等优势成为很有前途的给药系统。其中凝集素介导的第二代生物黏附给药系统具有特异靶向性，微粒制剂又在提高药物稳定性、控制药物释放等方面具有优势。

Lectin-mediated Bioadhesive Particulate Preparation:Status and Future Trends

The novel bioadhesive drug de livery systems have become very promising because of their advantages in targeti ng, extended and controlled release. Of those, the lectin-mediated bioadhesive delivery system has specific targeting. And the particulate preparation can impr ove drug's stability and control drug release. The above two reasons cause the l ectin-mediated bioadhesive particulate preparation to gain the most extensive a ttention. The current reviews focus on the second-generation bioadhesive mechan isms, bioadhesive materials, influence factors, their applications and future tr ends.