Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity |
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| Authors: | Nancy Gerits Werner Van Belle and Ugo Moens |
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| Affiliation: | (1) Department of Microbiology and Virology, Institute of Medical Biology, Faculty of Medicine, University of Troms?, N-9037 Troms?, Norway;(2) Department of Medical Genetics, University Hospital of Northern-Norway, N-9036 Troms?, Norway |
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| Abstract: | Background The mitogen-activated protein kinases, MAPKs for short, constitute cascades of signalling pathways involved in the regulation
of several cellular processes that include cell proliferation, differentiation and motility. They also intervene in neurological
processes like fear conditioning and memory. Since little remains known about the MAPK-Activated Protein Kinase, MAPKAPK5,
we constructed the first MAPKAPK knockin mouse model, using a constitutive active variant of MAPKAPK5 and analyzed the resulting
mice for changes in anxiety-related behaviour. |
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