乳化蒸发法制备固体脂质纳米粒

目的：采用乳化蒸发法制备固体脂质纳米粒,并考察其载药性能。方法：对影响固体脂质纳米粒质量的工艺因素和处方因素进行考察和优化设计,得到最优处方。选用模型药物酮洛芬制备载药固体脂质纳米粒,考察其包封率和体外释放行为。结果：所得固体脂质纳米粒平均粒径为（228.2±18.1）nm,多分散系数为（0.217±0.022）,ξ电位为-（21.4±0.6）mV。载药固体脂质纳米粒最佳包封率为（64.1±3.3）%,体外释放行为符合Weibull模型。结论：采用乳化蒸发法制备固体脂质纳米粒是可行的。

Preparation of Solid Lipid Nanoparticles by Emulsification-evaporation Technique

Objective： To prepare the solid lipid nanoparticles（SLN） by emulsification-evaporation technique, and to investigate the drug loading capacity of SLN. Methods： The influences of formulation and processing variables on the preparation and the quality of SLN were studied. The SLN containing Ketoprofen （KT-SLN） was prepared. The entrapment efficacy and drug release from SLN were assessed. Results： The mean size was （228.2 ± 18.1） nm with polydispersity index of （0. 217 ±0. 022） and the zeta potential was -（21.4 ± 0.6）mV. The best entrapment efficiency of KT-SLN was found to be （64.1 ± 3.3） % and the release profile in vitro was best fitted with Weibull distribution. Conclusion： Emulsification-evaporation technique could be used to prepare the solid lipid nanoparticles.