| EFFECTS OF INTERLEUKIN－4 ON GRANULOCYTE－MACROPHAGE－COLONY FORMATION FROM MURINE BONE MARROW CELLS AND HEMATOPOIETIC RECONSTIT |
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| 引用本文： | 朱康儿.EFFECTS OF INTERLEUKIN－4 ON GRANULOCYTE－MACROPHAGE－COLONY FORMATION FROM MURINE BONE MARROW CELLS AND HEMATOPOIETIC RECONSTIT[J].中国医学科学杂志,1994(2). |
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| 作者姓名： | 朱康儿 |
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| 作者单位： | Department of Hematology，First Affiliated Hospital，Zhejiang Medical University，Hangzhou 310003 |
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| 摘 要： | ＥＦＦＥＣＴＳＯＦＩＮＴＥＲＬＥＵＫＩＮ－４ＯＮＧＲＡＮＵＬＯＣＹＴＥ－ＭＡＣＲＯＰＨＡＧＥ－ＣＯＬＯＮＹＦＯＲＭＡＴＩＯＮＦＲＯＭＭＵＲＩＮＥＢＯＮＥＭＡＲＲＯＷＣＥＬＬＳＡＮＤＨＥＭＡＴＯＰＯＩＥＴＩＣＲＥＣＯＮＳＴＩＴＵＴＩＯＮＦＯＬＬＯＷＩＮ...
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EFFECTS OF INTERLEUKIN-4 ON GRANULOCYTE-MACROPHAGE-COLONY FORMATION FROM MURINE BONE MARROW CELLS AND HEMATOPOIETIC RECONSTITUTION FOLLOWING MURINE ALLOGENEIC BONE MARROW TRANSPLANTATION |
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| Zhu Kanger and Kerry Atkinson.EFFECTS OF INTERLEUKIN-4 ON GRANULOCYTE-MACROPHAGE-COLONY FORMATION FROM MURINE BONE MARROW CELLS AND HEMATOPOIETIC RECONSTITUTION FOLLOWING MURINE ALLOGENEIC BONE MARROW TRANSPLANTATION[J].Chinese Medical Sciences Journal,1994(2). |
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| Authors: | Zhu Kanger and Kerry Atkinson |
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| Abstract: | We investigated the effects of mouse recombinant IL-4 on hematopoiesis in vitro and in vivo. IL-4 alone was found to be incapable of stimulating colony formation, but it inhibited both IL-3-and GM-CSF-induced colony formation by murine hematopoietic progenitor cells. In contrast, colony formation induced by G-CSF was enhanced in the presence of IL-4. We also studied the influence of IL-4 on hematopoietic reconstiution after allogeneic bone marrow transplantation in a murine medel, and found that IL-4 had significant inhibitory effects on neutrophil recovery and that neutrophil recovery accelerated by IL-3 and G-CSF was significantly suppressed by IL-4. The combination of IL-4 and GM-SF caused a significant decrease in the absolute number of neutrophils. |
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| Keywords: | interleukin-4 hematopoietic progenitor bone marrow transplantation |
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