| 高效液相色谱-串联质谱法检测化妆品中糖皮质激素类违禁药物 |
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| 引用本文： | 王传现,刘罡一,倪昕路,韩丽,方晓明,张社.高效液相色谱-串联质谱法检测化妆品中糖皮质激素类违禁药物[J].分析仪器,2008(6). |
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| 作者姓名： | 王传现 刘罡一 倪昕路 韩丽 方晓明 张社 |
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| 作者单位： | 1. 上海出入境检验检疫局,上海,200135
2. 徐汇区中心医院,上海,200031 |
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| 基金项目： | 上海出入境检验检疫局科研经费资助项目 |
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| 摘 要： | 目的:建立固相萃取浓缩-高效液相色谱-串联质谱法测定化妆品中10种糖皮质激素类药物的方法.方法:样品经提取后,通过Oasis HLB固相萃取柱进行浓缩净化,用高效液相色谱-串联质谱法测定(以正离子电喷雾电离,检测方式为多级反应离子监测(MRM)),内标法定量.结果:糖皮质激素在5～150ng/mL范围内,线性相关系数均>0.99;在5～40 μg/kg添加水平,10种糖皮质激素的回收率为52.5%～112.5%,相对标准偏差(RSD)为3.21%～11.08%(n=6).结论:该方法具有快速、定量准确、检测灵敏等优点,适于化妆品中多种糖皮质激素药物的测定.
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| 关 键 词： | 糖皮质激素 化妆品 固相萃取 高效液相色谱-串联质谱法 |
Determination of glucocorticoids in cosmetics by HPLC-MS/MS. |
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| Wang Chuanxian,Liu Gangyi,Ni Xinlu,Han Li,Fang Xiaoming,Zhang She.Determination of glucocorticoids in cosmetics by HPLC-MS/MS.[J].Analytical Instrumentation,2008(6). |
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| Authors: | Wang Chuanxian Liu Gangyi Ni Xinlu Han Li Fang Xiaoming Zhang She |
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| Affiliation: | 1. Shanghai Entry-Exit Inspection and Quarantine Bureau;Shanghai;200135;2. Xuhui Hospital;200031 |
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| Abstract: | Objective:To establish a method for the determination of eleven glucocorticoids (prednisolone,meth- ylprednisolone,prednisone,dexamethasone,triamcinolone,betamethasone,triamcinolone acetonide, fludrocortisone acetate,beclomethasone,cortisone and flumethasone) in cosmetics by solid phase extrac- tion and HPLC-MS/MS.Methods:Various cosmetic samples were extracted with methanol under ultra- sonication.The extract was centrifuged and the upper solution was concentrated and purified by Oasis HLB solid phase extr... |
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