非高密度脂蛋白胆固醇水平与2型糖尿病微血管病变的相关性

目的：探讨非高密度脂蛋白胆固醇（non-HDL。C）水平与2型糖尿病（T2DM）微血管病变的相关性。方法：测定134例T2DM患者总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL—C）水平，根据公式non-HDL—C=TC—HDL-C计算出non—HDL—C含量，并与60例体检健康者（正常对照组）进行比较。结果：T2DM组TC、TG、LDL—C及non-HDL-C均高于正常对照组，T2DM合并微血管病变患者上述指标均高于T2DM无微血管病变患者（P〈0．05）；HDL-C明显低于T2DM无微血管病变患者（P〈0．05）。T2DM无微血管病变患者HDL-C略低于正常对照组（P〉0．05）。T2DM微血管病变与TC、TG、LDL—C、non-HDL—C等指标呈正相关，与HDL-C呈负相关，且non-HDL-C与T2DM微血管病变之间相关性优于TG、TC和LDL-C。结论：脂质代谢紊乱的敏感指标non—HDL-C与T2DM微血管病变之间具有较好的相关性。

Association between the levels of non-high density lipoprotein cholesterol and microangiopathy in type 2 diabetes

Objective： To investigate the correlation between the levels of non-high density lipoprotein cholesterol （ non- HDL- C ） and microangiopathy in type 2 diabetes （ T2DM ）. Methods： The levels of total cholesterol （ TC ）, triglyceride（TG）, high-density lipoprotein cholesterol （HDL-C ） and low-density lipoprotein cholesterol （LDL-C ） were detected in 134 patients with T2DM. The formula（ non-HDL-C = TC -HDL-C） was used to calculate the level of non- HDL- C, and then compared with 60 normal controls. Results： The level of TC, TG, LDL- C, and non-HDL-C in patients with T2DM were higher than those in control group, and the cases of T2DM with microangiopathy group were higher than those without microangiopathy group （P 〈 0.05 ） ; the level of HDL- C was significantly lower compared with without microangiopathy group （ P 〈 0.05 ）. There was no significant difference in the level of HDL-C between T2DM without microangiopathy group and control group. Furthermore, there was a positive correlation between T2DM with microangiopathy and TC, TG, LDL-C, non-HDL-C, and while there was a negative correlation between T2DM with microangiopathy and HDL-C, moreover, correlation of non-HDL-C was obviously stronger than that of TC, TG, and LDL-C. Conclusion： As a sensitive indicator of lipid metabolism disorders, it has much better correlation between non-HDL-C and type 2 diabetics with microangiopathy.