Comparison of [123I]metaiodobenzylguanidine kinetics with heart rate variability and plasma norepinephrine level |
| |
Authors: | Chinori Kurata Sakae Shouda Tadashi Mikami Yasushi Wakabayashi Tomoyasu Nakano Tsuyoshi Sugiyama Kei Tawarahara Kazuyuki Sakata |
| |
Affiliation: | (1) Department of Medicine III, Hamamatsu University School of Medicine, 3600 Handa-cho, 431-31 Hamamatsu, Japan;(2) Department of Medicine, Hamamatsu Red Cross Hospital, Hamamatsu, Japan;(3) Department of Cardiology, Shizuoka General Hospital, Shizuoka, Japan |
| |
Abstract: | Background 123I]Metaiodobenzylguanidine (MIBG) imaging has been used to assess cardiac sympathetic nerve abnormalities. We evaluated the
clinical significance of myocardial MIBG imaging as a measure of cardiac sympathetic nervous system function by comparing
it to heart rate variability and plasma norepinephrine level.
Methods and Results In 211 subjects, we analyzed heart rate variability with 24-hour electrocardiography, performed scintigraphy with MIBG, and
measured plasma norepinephrine levels. Time and frequency domain measures of heart rate variability were calculated with the
Marquette heart rate variability program (Marquette Electronics, Milwaukee, Wis.). Early and late myocardial MIBG uptakes
were measured at 15 and 150 minutes after injection, respectively. MIBG clearance rate from the heart and heart-to-lung and
heart-to-mediastinum ratios of MIBG activities were calculated. On the whole, heart rate variability, including low-frequency
power, correlated positively, but modestly so, with late MIBG uptake and negatively with MIBG clearance rate. The plasma norepinephrine
level correlated negatively with late MIBG uptake and with heart rate variability, including low-frequency power, and positively
with MIBG clearance rate. Similar correlations were also observed in patient subgroups with coronary artery disease, diabetes
mellitus, and renal failure, but these correlations were weak (R
2<0.5).
Conclusions Increased cardiac sympathetic nervous system activity may be associated with increased myocardial MIBG clearance and decreased
heart rate variability, including low-frequency power. Because these associations were not strong, however, the combination
of heart rate variability with MIBG may allow an interactive assessment of the cardiac autonomic nervous system. |
| |
Keywords: | sympathetic nervous system activity norepinephrine heart rate variability [123I]metaiodobenzylguanidine |
本文献已被 ScienceDirect SpringerLink 等数据库收录! |
|