普罗帕酮治疗窄QRS波室上性心动过速疗效分析

目的探讨普罗帕酮终止窄QRS波室上性心动过速的最佳给药方法。方法按完全随机法将符合入选标准的36例窄QRS波室上性心动过速患者分为观察组和对照组各18例。观察组给药剂量为1mg／kg，静脉2min推注完毕，并立即静脉推注5％葡萄糖10ml；对照组按1mg／kg取药，加5％葡萄糖10ml稀释后静脉推注，5min推注完毕。观察2组转复率、转复时间、不良反应发生率。结果给药速度越快，转复为窦性心律越快，不良反应发生率越低。观察组和对照组患者转复成功率分别为88．9％和77．8％，转复时间分别为（2．5±1．6）min和（4．1±2．3）min，2组转复成功率、转复时间差异无统计学意义（P〉0．05）。结论以1mg／kg普罗帕酮2min推注完毕能快速终止窄QRS波室上性心动过速的发生且不良反应发生率较低。

Curative effect of propafenone for treating narrow QRS wave paroxysmal supraventricular tachycardia

Objective To explore the curative effect of propafenone for treating narrow QRS wave paroxysmal supraventricular tachycardia. Methods Total 36 cases of patients were randomly divided into two groups A and B. Group A was intravenously injected 1 mg dosage of Propafenone per kilogram of body mass respectively. The intravenous injections lasted two minutes. Group B was intravenously injected on the base of group A respectively but the Propafenone were diluted with 10 ml of 5% glucose. The intravenously injections lasted 5 minutes. The cardioversion rate, cardioversion time and untoward reaction incidence rate of each group were observed. Results The fastersthe administration rates, the quicker the sinus rhythm appears and the lower the adverse Effect was. But the cardioversion success rate and cardioversion time showed no great difference. Conclusion The narrow QRS wave paroxysmal supraventricular tachycardia could be quickly stopped with intravenous injection of propafenone.