N-末端脑利肭肽与心衰并房颤患者复律问题的研究

目的 研究心衰并心房颤动的心脏病患者胺碘酮复律前血浆N-末端脑钠肽前体水平对复律效果的预测价值.方法 150例心衰并心房颤动的心脏病患者接受静脉滴注胺碘酮5～7 mg/kg,30～60 min内滴完,复律治疗,观察患者复律前后血浆N末端脑钠肽前体(NT-proBNP)水平变化.结果 150例阵发性房颤患者服药后48 h内100例(66.67％)转复为窦性心律,成功复律组患者复律前血浆NT-proBNP水平为(967.04±366.16)ng/L,明显低于未成功复律组(1 182.04±298.34) ng/L(P＜0.01);成功复律组患者复律后1h血浆NT-proBNP水平为(496.21±142.54)ng/L,明显低于复律前(967.04±366.16)ng/L(P＜0.01);而未成功复律组血浆NT-proBNP水平复律前(1 182.04±298.34)ng/L,与服药后48 h(996.76±351.28) ng/L比较无明显变化(P＜0.05).结论 入院时血浆NT-proBNP水平对心衰并心房颤动的心脏病患者药物复律效果具有预测价值.

Study on relationship between NT-BNP and cardioversion of patient with heart failure combined with atrial fibrillation

Objective Before cardioversion with Amiodarone in patient with heart failure（HF） combined with atrial fi- brillation（AF） ,to make a study about the predictive value of NT-pro BNP level for cardioversion effect. Methods To observe the level changes of NT-pro BNP of 160 patients with I-IF combined with AF between before and after cardioversion with intravenous Amiodarone 5-7 mg/kg,dropping over with in 30 to 60 minutes. Result After 150 cases with paroxysmal taking drug, within 48 hours, 100 patients （66.67% ） converted sinus rhythm, before cardio- version, plasma NT-pro BNP level about successful cardioerter groups was （967.04±366.16） ng/L,obviously lower than unsuccessfully cardioerter group（ 1 182.04± 298.34 ） ng/L （ P〈0.01 ）, after cardioversion for 1 hour, plasma NT-pro BNP level of successful cardioerter groups was （496. 21± 142. 54） ng/L, obviously lower than before （967.04± 366.16） ng/L（P〈0.01 ）,before cardioversion, but plasma NT-pro BNP level of unsuccessful group was （1 182.04±298.34） ng/L,Compared with after medication for 48 hours（996. 76±351.28） ng/L,had no change（P 〈0. 05）. Conclusion Plasma NT-pro BNP level has forecast values for drug cardioversion effect in hospitalized patients with HF combined with AF.