| 低频超声辐射对融合蛋白PTD-SOD渗透离体皮肤的影响 |
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| 引用本文： | 赵林,谢艳招,潘剑茹,刘树滔.低频超声辐射对融合蛋白PTD-SOD渗透离体皮肤的影响[J].辐射研究与辐射工艺学报,2011,29(2):99-103. |
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| 作者姓名： | 赵林 谢艳招 潘剑茹 刘树滔 |
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| 作者单位： | 福建师范大学闽南科技学院;福州大学生物工程研究所; |
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| 基金项目： | 福建省教育厅B类项目(JB09079)资助 |
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| 摘 要： | 通过小鼠的离体皮肤渗透,研究了低频超声(40 kHz)辐射对融合了蛋白转导域的超氧化物歧化酶(Proteintransduction domain-superoxide dismutase,PTD-SOD)体外经皮渗透的影响.结果表明,透皮8h时,低频超声与氮酮(Azone)的增渗比分别为3.40和2.52;低频超声作...
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| 关 键 词： | 经皮渗透 低频超声 蛋白转导域 超氧化物歧化酶 |
Effect of low-frequency ultrasound on trans-dermal permeation of fusion protein PTD-SOD in vitro |
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| ZHAO Lin,XIE Yanzhao,PAN Jianru,LIU Shutao.Effect of low-frequency ultrasound on trans-dermal permeation of fusion protein PTD-SOD in vitro[J].Journal of Radiation Research and Radiation Processing,2011,29(2):99-103. |
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| Authors: | ZHAO Lin XIE Yanzhao PAN Jianru LIU Shutao |
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| Affiliation: | ZHAO Lin1,2 XIE Yanzhao1 PAN Jianru2 LIU Shutao2 1(Minnan Science and Technology Institute Fujian Normal University,Quanzhou 362332,China) 2(Institute of Biotechnology,Fuzhou University,Fuzhou 350002,China) |
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| Abstract: | By means of trans-dermal permeation on rat skin in vitro,the effect of low-frequency ultrasound(40 kHz) on trans-dermal permeation of(Protein transduction domain-superoxide dismutase,PTD-SOD) has been inves-tigated.The results show that the enhancement ratios of ultrasound and Azone are 3.40 and 2.52,respectively,when the trans-dermal permeation time is 8 h.In the presence of low-frequency ultrasound,when the initial pH value of drug solution is 6.0,the activity of PTD-SOD in receiver cell reaches 1598.00 U... |
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| Keywords: | Trans-dermal permeation Low-frequency ultrasound Protein transduction domain(PTD) Superox ide dismutase(SOD) |
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