| 基于多糖受体理论的黄芪多糖质量控制研究思路 |
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| 引用本文： | 曹宇欣,李科,秦雪梅,焦思明,杜昱光,李先荣.基于多糖受体理论的黄芪多糖质量控制研究思路[J].中草药,2019,50(9):2201-2209. |
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| 作者姓名： | 曹宇欣 李科 秦雪梅 焦思明 杜昱光 李先荣 |
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| 作者单位： | 山西大学 中医药现代研究中心, 山西 太原 030006,山西大学 中医药现代研究中心, 山西 太原 030006;中国科学院过程工程研究所, 北京 100190,山西大学 中医药现代研究中心, 山西 太原 030006,中国科学院过程工程研究所, 北京 100190,中国科学院过程工程研究所, 北京 100190,山西健硕食品药品研究院有限公司, 山西 太原 030000 |
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| 基金项目： | 国家自然科学基金资助项目（81872962）；山西省优秀人才科技创新项目（201605D211030）；山西省优秀人才科技创新项目（201705D211020）；山西省重点研发计划重点项目（201603D311101）；国家中药标准化项目（ZYBZH-Y-JIN-34）；山西省科技攻关项目（20150313004-5） |
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| 摘 要： | 黄芪是我国常用的大宗中药材,具有很高的药用及食用价值。其化学成分主要包括皂苷类、黄酮类、多糖类及氨基酸类等。其中黄芪多糖(Astragalus polysaccharide,APS)作为黄芪的主要活性成分因其非专属性和可控性不强等问题,未能作为质控指标评价黄芪种质资源。多糖受体理论的提出和应用为解决多糖类药品质控的国际性难题提供了新思路。综述了近年来黄芪多糖质量控制与多糖受体理论的研究进展,并提出了黄芪寡糖活性中心的质控研究思路。
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| 关 键 词： | 黄芪多糖 构效关系 质量控制 多糖受体理论 多糖活性中心 |
| 收稿时间： | 2019/1/6 0:00:00 |
Research approach on quality control of Astragalus polysaccharides based on polysaccharide receptor theory |
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| CAO Yu-xin,LI Ke,QIN Xue-mei,JIAO Si-ming,DU Yu-guang and LI Xian-rong.Research approach on quality control of Astragalus polysaccharides based on polysaccharide receptor theory[J].Chinese Traditional and Herbal Drugs,2019,50(9):2201-2209. |
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| Authors: | CAO Yu-xin LI Ke QIN Xue-mei JIAO Si-ming DU Yu-guang and LI Xian-rong |
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| Affiliation: | Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China,Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China;Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China,Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China,Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China,Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China and Shanxi Jianshuo Food and Drug Research Institute Co., Ltd., Taiyuan 030000, China |
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| Abstract: | Astragali Radix is a commonly used staple Chinese herbal medicine with high medicinal and edible value. Its chemical composition mainly contains saponins, flavonoids, polysaccharides, and amino acids. Among them, Astragalus polysaccharides (APS), as the main active component of Astragali Radix, failed to be used as a quality control index to evaluate germplasm resources due to its non-specificity and weaker controllability. The proposal and application of polysaccharide receptor theory provides a new way to solve the international problem of quality control of polysaccharide drugs. In this paper, several related research literatures on the quality control of polysaccharides from Astragali Radix and polysaccharide receptor theory in recent years were reviewed, and the research ideas of quality control of Astragalus oligosaccharide active center were proposed. |
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| Keywords: | Astragalus polysaccharides structure-activity relationship quality control polysaccharide receptor theory polysaccharide active center |
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