稳心颗粒联合氨氯地平治疗冠心病心绞痛的临床研究

目的研究稳心颗粒联合苯磺酸氨氯地平片治疗冠心病心绞痛的临床疗效。方法选取2016年10月—2018年10月在遂宁市中心医院进行治疗的132例冠心病心绞痛患者作为研究对象,将患者随机分为对照组和治疗组,每组各66例。对照组患者口服苯磺酸氨氯地平片,1片/次,1次/d;治疗组在对照组治疗的基础上口服稳心颗粒,1袋/次,3次/d。两组患者均治疗1个月。观察两组患者的临床疗效和心电图疗效,同时比较两组治疗前后的临床症状、血清学指标和心肌酶指标。结果治疗后,对照组临床疗效和心电图疗效分别为81.82%、83.33%,均分别显著低于治疗组的95.45%、93.94%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者心绞痛发作次数和持续时间均显著降低,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组心绞痛发作次数和持续时间显著短于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组全血黏度(WBV)、血浆黏度(PV)、纤维蛋白原(FIB)和C反应蛋白(CRP)水平均显著降低,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组血清学指标水平显著低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者肌酸激酶(CK)、肌酸激酶MB型同工酶(CK-MB)水平均显著降低,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组心肌酶指标水平显著低于对照组,两组比较差异具有统计学意义(P0.05)。结论稳心颗粒联合苯磺酸氨氯地平片治疗冠心病心绞痛具有较好的临床疗效,可改善患者临床症状和血液流变学指标,安全性较高,具有一定的临床推广应用价值。

Clinical study on Wenxin Granules combined with amlodipine in treatment of angina pectoris of coronary heart disease

Objective To study the clinical efficacy of Wenxin Granules combined with Amlodipine Besylate Tablets in treatment of angina pectoris of coronary heart disease. Methods Patients (132 cases) with angina pectoris of coronary heart disease in Suining Central Hospital from October 2016 to October 2018 were randomly divided into control and treatment groups, and each group had 66 cases. Patients in the control group were po administered with Amlodipine Besylate Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Wenxin Granules on the basis of control group, 1 bag/time, three times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacy and electrocardiogram efficacy were evaluated, and the clinical symptoms, serological indicators, and myocardial enzyme indexes in two groups before and after treatment were compared. Results After treatment, the clinical and electrocardiogram efficacy in the control group were 81.82% and 81.82%, which were significantly lower than 95.45% and 95.45% in the treatment group, respectively, and there were differences between two groups (P < 0.05). After treatment, angina attack frequency and duration in two groups were significantly reduced, the difference was statistically significant in the same group (P < 0.05). And the angina attack frequency and duration in the treatment group were significantly shorter than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of WBV, PV, FIB, and CRP in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the serological indicators in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, CK and CK-MB levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And myocardial enzyme indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Wenxin Granules combined with Amlodipine Besylate Tablets has a good effect in treatment of angina pectoris of coronary heart disease, can improve the clinical symptoms and hemorheological indexes, with high safety, which has a certain clinical application value.