| 单核苷酸多态性与高度近视发生发展的研究进展 |
| |
| 引用本文： | 吴姗姗,郭大东,刘德政,殷玲玲,蒋文君,毕宏生.单核苷酸多态性与高度近视发生发展的研究进展[J].国际眼科杂志,2019,19(9):1495-1498. |
| |
| 作者姓名： | 吴姗姗 郭大东 刘德政 殷玲玲 蒋文君 毕宏生 |
| |
| 作者单位： | 中国山东省济南市,山东中医药大学; 中国山东省济南市,山东省中西医结合眼病防治重点实验室 山东省高校中西医结合眼病防治技术(强化)重点实验室 山东中医药大学眼科研究所,中国山东省济南市,山东省中西医结合眼病防治重点实验室 山东省高校中西医结合眼病防治技术(强化)重点实验室 山东中医药大学眼科研究所,中国山东省济南市,山东中医药大学; 中国山东省济南市,山东省中西医结合眼病防治重点实验室 山东省高校中西医结合眼病防治技术(强化)重点实验室 山东中医药大学眼科研究所,中国山东省东营市人民医院,中国山东省济南市,山东省中西医结合眼病防治重点实验室 山东省高校中西医结合眼病防治技术(强化)重点实验室 山东中医药大学眼科研究所,中国山东省济南市,山东省中西医结合眼病防治重点实验室 山东省高校中西医结合眼病防治技术(强化)重点实验室 山东中医药大学眼科研究所; 中国山东省济南市,山东中医药大学附属眼科医院 |
| |
| 基金项目： | 国家自然科学基金项目(No.81603421); 山东省重点研发计划(No.2019GSF108252,2017CXGC1211) |
| |
| 摘 要： | 目前，近视已成为一种全球性公共卫生疾病，其发生多是由遗传和环境等因素引起。单核苷酸多态性(SNPs)是指在基因组水平上发生的、由单个碱基的改变引起的脱氧核糖核酸(DNA)序列多态性。近年来有文献报道，相关基因位点上的SNPs的变化与近视的发生发展密切相关。本文就近视相关基因的SNPs与近视发生发展的关联研究现状作一综述，以期为近视病因和病理机制的研究提供新的思路。
|
| 关 键 词： | 近视 单核苷酸多态性 等位基因 基因突变 易感性 |
| 收稿时间： | 2019/3/6 0:00:00 |
| 修稿时间： | 2019/7/31 0:00:00 |
Research progress of single nucleotide polymorphism and development of high myopia |
| |
| Shan-Shan Wu,Da-Dong Guo,De-Zheng Liu,Ling-Ling Yin,Wen-Jun Jiang and Hong-Sheng Bi.Research progress of single nucleotide polymorphism and development of high myopia[J].International Journal of Ophthalmology,2019,19(9):1495-1498. |
| |
| Authors: | Shan-Shan Wu Da-Dong Guo De-Zheng Liu Ling-Ling Yin Wen-Jun Jiang and Hong-Sheng Bi |
| |
| Affiliation: | Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China; Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention an Therapy of Ocular Disease in University of Shandong, Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, China,Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention an Therapy of Ocular Disease in University of Shandong, Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, China,Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China; Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention an Therapy of Ocular Disease in University of Shandong, Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, China,People''s Hospital of Dongying City, Dongying 257091, Shandong Province, China,Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention an Therapy of Ocular Disease in University of Shandong, Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, China and Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention an Therapy of Ocular Disease in University of Shandong, Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, China; Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, China |
| |
| Abstract: | At present, myopia has become a public health disease worldwide, and its occurrence is mostly caused by genetic and environmental factors. Single nucleotide polymorphisms(SNPs)are the changes in single base at the genomic level caused by DNA sequence polymorphisms. In recent years, it is reported that the change of SNPs in myopic related gene loci is closely related to the occurrence and development of myopia. The present paper reviewed the current status of the association between SNPs of myopia-related genes and the development of myopia, providing a new insight into the future research of pathogenesis of myopia. |
| |
| Keywords: | myopia single nucleotide polymorphisms allele gene mutation susceptibility |
|
| 点击此处可从《国际眼科杂志》浏览原始摘要信息 |
|
点击此处可从《国际眼科杂志》下载全文 |
|
