2015—2017年西安市中心医院保肝药物的使用情况分析

目的 分析西安市中心医院2015-2017年保肝药物的使用情况，为临床合理应用及管理提供参考。方法 调取西安市中心医院2015-2017年保肝药物的临床使用数据，对保肝药物品种、用量、销售金额、用药频度（DDDs）、日均费用（DDC）和药品排序比（B/A）进行统计分析。结果 保肝药物的销售金额呈下降趋势，但占比基本稳定；销售金额前3位的科室为血研所、消化科、普Ⅱ科，复方甘草酸苷注射液的使用频率最高，其次为注射用还原型谷胱甘肽、注射用门冬氨酸鸟氨酸，DDC最高的是异甘草酸镁注射液，最低的为葡醛内酯片。大多数药品的B/A为0.5~2，同步性较好。结论 西安市中心医院保肝药物的使用基本合理，但同时也存在一些不合理用药的情况，需持续关注。

Analysis on application of liver-protecting drugs in Xi'an Central Hospital from 2015 to 2017

Objective To analyze the application of liver-protecting drugs in Xi''an Central Hospital from 2015 to 2017, so as to provide reference for rational use and management of liver-protecting drugs. Methods The data of the clinical use of liver-protecting drugs were collected in Xi''an Central Hospital from 2015 to 2017. Then, the rationality of these drugs was evaluated retrospectively in terms of consumption sum, defined daily dosed (DDDs), defined daily cost (DDC), and drug sequence ration (B/A). Results Consumption sum of liver-protecting drugs had the trend of decrease on the whole, The top 3 departments of liver-protecting drugs in consumption sum were Department of Hematologists, Department of Digestive, and Department of General Surgery II. DDDs of Compound Glycyrrhizin Injection, Reduced Glutathione for injection, and Ornithine Aspartate for injection ranked the top three. DDC of Magnesium Isoglycyrrhizinate Injection was the highest, while DDC of Gluconolactone Tablets was the lowest. B/A of most drugs were between 0.5 and 2, indicating that the synchronism was better. Conclusion The application of liver-protecting drugs are basically reasonable in Xi''an Central Hospital, but there are still some individual drugs to be continuously improved.