Structure elucidation of new oleanane‐type glycosides from three species of Acanthophyllum |
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| Authors: | Gaoussou Timité Anne‐Claire Mitaine‐Offer Tomofumi Miyamoto Mohammad Ramezani Abdolhossein Rustaiyan Jean‐François Mirjolet Olivier Duchamp Marie‐Aleth Lacaille‐Dubois |
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| Affiliation: | 1. Laboratoire de Pharmacognosie, UMIB, UPRES EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 bd. Jeanne D' Arc, BP 87900, 21079 Dijon Cedex, France;2. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan;3. Department of Pharmacognosy and Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775 1365 Mashhad, Iran;4. Department of Chemistry, Shahid Beheshty University, Eveen, Tehran, Iran;5. Oncodesign, 20 rue Jean Mazen, BP 27627, 21076 Dijon Cedex, France |
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| Abstract: | From the roots of three species of Acanthophyllum (Caryophyllaceae), two new gypsogenic acid glycosides, 1 and 2, were isolated, 1 from A. sordidum and A. lilacinum, 2 from A. elatius and A. lilacinum, together with three known saponins, glandulosides B and C, and SAPO50. The structures of 1 and 2 were established mainly by 2D NMR techniques as 23‐O‐β‐D ‐galactopyranosylgypsogenic acid‐28‐O‐β‐D ‐glucopyranosyl‐(1→3)‐β‐D ‐glucopyranosyl‐(1→6)]‐β‐D ‐galactopyranoside (1) and gypsogenic acid‐28‐O‐β‐D ‐glucopyranosyl‐(1→3)‐β‐D ‐glucopyranosyl‐(1→6)]‐β‐D ‐galactopyranoside (2). The cytotoxicity of several of these saponins was evaluated against two human colon cancer cell lines (HT‐29 and HCT 116). Copyright © 2010 John Wiley & Sons, Ltd. |
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| Keywords: | NMR 1H 13C 2D NMR triterpene saponins gypsogenic acid Caryophyllaceae Acanthophyllum |
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