| 稳定同位素标记苏丹红Ⅰ-D_5的合成研究 |
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| 引用本文： | 卢浩,孙雯,徐仲杰.稳定同位素标记苏丹红Ⅰ-D_5的合成研究[J].化学试剂,2017,39(11). |
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| 作者姓名： | 卢浩 孙雯 徐仲杰 |
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| 作者单位： | 上海化工研究院技术开发中心,上海,200062 |
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| 基金项目： | “十二五”后科技支撑计划项目 |
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| 摘 要： | 以廉价易得的苯-D6为起始原料,经硝化、还原、重氮化、偶合生成苏丹红Ⅰ-D5。以消耗的苯-D6计算,苏丹红Ⅰ-D5的总收率可达82.2%。采用1HNMR和ESI-MS等确定产品结构信息,产品的同位素丰度为99.1 atom%D,纯度为99.5%。该化合物可作为食品安全检测领域非法添加物质苏丹红Ⅰ检测的稳定同位素内标试剂。
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| 关 键 词： | 合成 稳定同位素 苏丹红Ⅰ-D5 食品安全 |
Synthesis of Sudan Ⅰ-Ds Labeled with Stable Isotope |
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| LU Hao,SUN Wen,XU Zhong-jie.Synthesis of Sudan Ⅰ-Ds Labeled with Stable Isotope[J].Chemical Reagents,2017,39(11). |
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| Authors: | LU Hao SUN Wen XU Zhong-jie |
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| Abstract: | This work presents an efficient and convenient synthesis method of sudan Ⅰ-D5 with benzene-D6 as the common substrate,which is mainly obtained via nitration,reduction,diazotization and a coupling reaction.The yields of sudan Ⅰ-D5 was 82.2％ based on benzene-D6 consumed.The product's structures were confirmed by 1 HNMR and ESI-MS.The chemical purity of this product is 99.5％ and deuterium isotopic enrichment of this product is 99.1 atom％ D.The compound could be used in the field of food safety testing as stable isotope internal standard reagent. |
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| Keywords: | synthesis stable isotope Sudan Ⅰ-D5 food safety |
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