西瓜藤提取物的抑菌作用研究

采用琼脂稀释法研究西瓜藤提取物的体外抑菌作用,用小鼠腹腔注射金黄色葡萄球菌法研究80%醇提物的体内抑菌作用。结果表明:西瓜藤提取物对金黄色葡萄球菌、大肠埃希氏菌、铜绿假单胞菌、伤寒沙门氏菌、枯草芽孢杆菌和肺炎克雷伯氏菌均有不同程度的抑制作用,但对链球菌作用不明显。其中80%醇提取物和乙酸乙酯萃取物抑制金黄色葡萄球菌活性最好,其最低抑菌浓度(MIC)分别为4.2、8.4mg.mL-1。体内实验也表明,乙醇提取物具有较好的抑菌作用。西瓜藤提取物具有抑菌活性,在抑菌方面有一定开发前景。

Antimicrobial activity of the extracts from Citrullus vulgaris Schrad vine

Agar dilution method was applied to detect the antimicrobial effects of Citrullus vulgaris Schrad vine extract in vitro,and the mice celiac injection of staphylococcus aureus method was applied to detect the antimicrobial effect of C.vulgaris Schrad of 80% alcohol extract in vitro,in order to study antimicrobial activity in vitro of C.vulgaris Schrad vine extract.C.vulgaris Schrad vine extract had different inhibition effects on staphylococcus aureus,escherichia coli,bacillus aeruginosus,salmonella typh,bacillus subtilis and klebsiella pneumoniae,but it showed weak inhibition effect on chain coccus.Effects of 80 % alcohol extract and ethyl acetate extract were better than others on staphylococcus aureus.The minimum inhibition concentration(MIC),was 4.2 mg·mL-1,8.4 mg·mL-1 respectively.C.vulgaris Schrad vine extract had antibacterial action,and would provide a basis to exploit new antimicro-bic drug.