| 高温致厚朴SFE-CO2萃取物中厚朴酚、和厚朴酚降解 |
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| 引用本文： | 苏子仁,董婷霞,卢振强,詹华强.高温致厚朴SFE-CO2萃取物中厚朴酚、和厚朴酚降解[J].药学学报,2002,37(11):870-875. |
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| 作者姓名： | 苏子仁 董婷霞 卢振强 詹华强 |
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| 作者单位： | [1]广州中医药大学，广东广州510405 [2]香港科技大学生物系暨生物技术研究所，香港 |
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| 基金项目： | DAGgrantfromHKUST (DAG0 0 0 1.SC12andFO14 9toK .W .K T)，theFoundationofChineseNaturalSciences (Nationa1“ 9 5”ScientificProgramme) . |
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| 摘 要： | 目的了解影响厚朴中有效成分厚朴酚、和厚朴酚的不稳定因素。方法用HPLC法测定在不同实验条件下,厚朴SFE-CO2萃取物中厚朴酚、和厚朴酚的含量;用加速实验测定有效期。结果厚朴酚、和厚朴酚的有效期(25℃)分别为387 d和476 d。结论温度是影响厚朴酚、和厚朴酚有效期的最主要因素, 降解符合一级速度反应。
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| 关 键 词： | 厚朴 厚朴酚 和厚朴酚 SFE-CO2 稳定性 |
| 收稿时间： | 2001-11-27 |
HEAT-INDUCED DEGRADATION OF MAGNOLOL AND HONOKIOL IN SUPERCRITICAL FLUID CO2 EXTRACTION OF CORTEX Magnolia officinalis (HOUPO) |
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| SU Zi-ren,DONG Ting-xia,LO Chun Keung,TSIM Wah Keung Karl.HEAT-INDUCED DEGRADATION OF MAGNOLOL AND HONOKIOL IN SUPERCRITICAL FLUID CO2 EXTRACTION OF CORTEX Magnolia officinalis (HOUPO)[J].Acta Pharmaceutica Sinica,2002,37(11):870-875. |
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| Authors: | SU Zi-ren DONG Ting-xia LO Chun Keung TSIM Wah Keung Karl |
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| Abstract: | AIMTo elucidate the factors that affect the stability of magnolol and honokiol in Cortex Magnolia officinalis (Houpo) in the process of extraction. METHODSThe contents of magnolol and honokiol in Houpo SFE-CO2 extract, treated on different conditions, were determined by HPLC. The shelf lives of magnolol and honokiol were also estimated. RESULTS The shelf lives of magnolol and honokiol were found to be 387 days and 476 days respectively at 25℃. CONCLUSIONTemperature is the main factor that affects the stability of magnolol and honokiol. The degradation is in accord with the first order rate of reaction. High temperature should be avoided during the extraction, figuration and storage of the products. |
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| Keywords: | Magnolia officinalis magnolol honokiol SFE-CO_2 stability |
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