| TREATMENT OF 23 PATIENTS WITH ADVANCED GASTRIC CANCER BY INTRAVENOUSLY TRANSFER OF AUTOLOGOUS TUMOR－INFILTRATING LYMPHOCYTES |
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| 引用本文： | 许祥裕,徐立春,丁树标,吴明生,唐治华,伏文钧,倪庆.TREATMENT OF 23 PATIENTS WITH ADVANCED GASTRIC CANCER BY INTRAVENOUSLY TRANSFER OF AUTOLOGOUS TUMOR－INFILTRATING LYMPHOCYTES[J].中国医学科学杂志,1995(3). |
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| 作者姓名： | 许祥裕 徐立春 丁树标 吴明生 唐治华 伏文钧 倪庆 |
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| 作者单位： | Military Medical Institute，Nanjing Military Area，Nanjing 210002 |
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| 摘 要： | ＴＲＥＡＴＭＥＮＴＯＦ２３ＰＡＴＩＥＮＴＳＷＩＴＨＡＤＶＡＮＣＥＤＧＡＳＴＲＩＣＣＡＮＣＥＲＢＹＩＮＴＲＡＶＥＮＯＵＳＬＹＴＲＡＮＳＦＥＲＯＦＡＵＴＯＬＯＧＯＵＳＴＵＭＯＲ－ＩＮＦＩＬＴＲＡＴＩＮＧＬＹＭＰＨＯＣＹＴＥＳＣＯＭＢＩＮＥＤＷＩＴＨｒＩＬ...
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TREATMENT OF 23 PATIENTS WITH ADVANCED GASTRIC CANCER BY INTRAVENOUSLY TRANSFER OF AUTOLOGOUS TUMOR-INFILTRATING LYMPHOCYTES COMBINED WITH rIL-2 |
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| Xu Xiangyu,Xu Lichun,Ding Shubiao,Wu Mingsheng,Tang Zhihua,Fu Wenjun and Ni Qing.TREATMENT OF 23 PATIENTS WITH ADVANCED GASTRIC CANCER BY INTRAVENOUSLY TRANSFER OF AUTOLOGOUS TUMOR-INFILTRATING LYMPHOCYTES COMBINED WITH rIL-2[J].Chinese Medical Sciences Journal,1995(3). |
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| Authors: | Xu Xiangyu Xu Lichun Ding Shubiao Wu Mingsheng Tang Zhihua Fu Wenjun and Ni Qing |
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| Abstract: | Tumor-infiltrating lymphocytes (TIL)isolated from metastatic lymph nodes in patients with nonoperable advanced gastric cancer were induced to become LAK-like cytotoxic activrty of TIL after in vitro culture with rlL-2.Twenty-three patients with advanced gastric cancer were treated by intravenously transfer of autologous TIL combined with rlL-2. The tumor forus disappeared (complete remission, CR) in 3 patients (13. 0%) and significantly decreased (partial remission, PR) in 5 patients (21. 7%). Fifteen patients did not respond to the treatment. The amount of soluable IL-2 receptor in serum was significantly decreased after treatment, the cytotoxicity of NK cells and OT test were significantly increased. No significant difference in CD4/CD8 was found between before and after treatment. No serious side effect was obseved in the treatment. |
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| Keywords: | tumor infiltrating lymphocyte interleukin-2 (IL2) advanced gastric cancer |
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