Conjunctival epithelial cells from patients with Sjögren's syndrome inappropriately express major histocompatibility complex molecules,La(SSB) antigen,and heat-shock proteins |
| |
| Authors: | Dimitri I Yannopoulos Stéphane Roncin Armelle Lamour Yvon L Pennec Haralampos M Moutsopoulos Pierre Youinou |
| |
| Affiliation: | (1) Laboratory of Immunology, Brest University Medical School Hospital, F29609 Brest Cedex, France;(2) Unit of Ophthalmology, Brest University Medical School, Brest, France;(3) Department of Internal Medicine, Brest University Medical School, Brest, France |
| |
| Abstract: | The La(SSB) antigen has been detected within the cytoplasm and on the membrane of conjunctival cells (CC) from patients with Sjögren's syndrome, whereas it was weakly expressed in the nucleus of normal cells. The diseased CC were shown to overproduce major histocompatibility complex (MHC) class I antigens and express MHC class II antigens. Anti-heat-shock protein monoclonal antibody bound to the cell membrane in patients but not in normal controls.On sabbatical leave from Department of Internal Medicine, Medical School, Ioannina, Greece. |
| |
| Keywords: | Sjö gren's syndrome La(SSB) antigen epithelial cells |
| 本文献已被 SpringerLink 等数据库收录！ |
|
