蛋白质组学在中医证候学研究中的应用进展

对中医证候微观物质基础的研究是中医学现代化研究的重要方面,"证"的整体性、模糊性、动态性、差异性、复杂性的特点,又使得中医"证"通过现代实验室检查所得到的单一理化指标缺乏足够的特异性。以蛋白质组学为代表的系统生物学技术的出现使现代医学由还原论思维走向了整体思维,也使得中医的理念有了数理化的可能。蛋白质组学在中医学证候的研究中取得了一系列的进展,在动物证候模型及中医"病证结合"的研究中的得到了广泛的应用,为中医证候学的研究提供了大量的研究数据及广阔的视野。

Progress Of TCM Syndrome Research With Proteomics

It is a major aspect of modernized research on Traditional Chinese Medicine (TCM) to study the micro substance as the basic for TCM syndrome. On account of the integrality, ambiguity, variability, diversity and complexity of TCM syndrome, single physical and chemical indicators out of modern laboratory cannot embody the meaning of TCM syndrome. The development of systems biology featuring proteomics, brings systematic thinking to modern medicine on the basis of reductionism. Systematic thinking makes it possible to objectify TCM syndrome. It coincides with TCM in the concept of integrality, variability, informatization and complexity. A lot of achievements have been made in the research of TCM syndrome by proteomic technology. The technology has been be widely used in the research of the animal model of the syndrome and combination of disease and syndrome. A mass of data has been accumulated that offers a broad future for the research of TCM syndrome.