降解纤维素的“超分子机器”研究进展

综述了目前关于纤维小体组装模式、纤维小体结构多样性及人工设计纤维小体等方面的研究进展.纤维小体是某些厌氧菌产生的由多个亚基共同组装而成的大分子机器,是致力于组织、协调多种酶组分协同高效催化降解木质纤维素的胞外蛋白质复合体.纤维小体是厌氧微生物水解纤维素的主体,具有非常高效的打破结晶纤维素的结晶结构和降解纤维素链的作用.纤维小体对木质纤维素降解的高效性来自于其自发组装而成的复杂的高级结构,其结构的复杂性因不同的厌氧微生物而有所不同.

Research Advances on The Assembly Mode of Cellulosomal Macromolecular Complexes

Cellulosomes produced by certain anaerobic microbes are commonly assembled from multiple subunits to macromolecular machines, and are extracellular protein complexes, which could organize and coordinate a variety of enzymic components to synergistically and effectively degrade lignocelluloses. Cellulosomes are the main forces of anaerobic hydrolytic celluloses, and play a vital role in breaking and using crystalline celluloses. The highly-efficient degradation on lignocelluloses of cellulosomes come from their self-assembled complex high-level structures, and the complex structures of the different anaerobic microorganisms have the astonishing diversity. The research advances on the diversity of assembly mode, structure, and the artificial design of cellulosomes were introduced.