| N-甲基吗啉含量测定方法研究 |
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| 引用本文： | 安巧,梁光义,黄正明,等.N-甲基吗啉含量测定方法研究[J].辽宁化工,2014(1):111-113. |
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| 作者姓名： | 安巧 梁光义 黄正明 等 |
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| 作者单位： | [1]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550002 [2]中国人民解放军第三○二医院,北京100039 [3]天津药物研究院,天津300193 [4]贵州百灵企业集团制药股份有限公司,贵州安顺561000 |
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| 基金项目： | “十二五”国家重大新药创制科技重大专项（20l1Zx09102-009-002）;贵州省中药现代化科技产业研究开发专项（黔科合中药字[2012]5054）;贵州省创新人才基地（黔人领发[2011]1号）. |
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| 摘 要： | 建立测定N-甲基吗啉含量测定的非水滴定法。以醋酐作溶剂,结晶紫作指示剂,照指示剂法用高氯酸滴定液滴定。本法测定值的相对标准偏差RSD均小于2%。本法操作简单,滴定终点清晰,重复性好,可作为测定N-甲基吗啉含量的方法。
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| 关 键 词： | N-甲基吗啉 含量测定 非水滴定法 |
Research on Determination of N-methylmorpholine Content |
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| AN Qiao,LIANG Guang-yi,HUANG Zheng-ming,LIU Chang-xiao,XIA Wen,CAO Pei-xue.Research on Determination of N-methylmorpholine Content[J].Liaoning Chemical Industry,2014(1):111-113. |
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| Authors: | AN Qiao LIANG Guang-yi HUANG Zheng-ming LIU Chang-xiao XIA Wen CAO Pei-xue |
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| Affiliation: | 1. The Key laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guizhou Guiyang 550002, China; 2. 302 Hospital of PLA, Beijing 100039, China; 3. Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China; 4. Guizhou Bailing Enterprise Group Pharmaceutical Co., Ltd., Guizhou Anshun 561000, China) |
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| Abstract: | A non-aqueous titration method to determine N-methylmorpholine content was established. The non-aqueous titration method was performed with acetic anhydride as solvent, perchloric acid as titrant, crystal violet as indicator. Relative standard deviations （RSD） of the determined values were less than 2%. The method has the advantages of easy operation, clear titration endpoint and good repeatability. The method can be used to determine the content of N-methylmorpholine. |
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| Keywords: | N-methylmorpholine determination non-aqueoustitration |
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