既往有心脑血管病对严重急性呼吸综合征患者病死率的影响

目的研究心脑血管基础疾病对严重急性呼吸综合征(SARS)患者病死率的影响。方法分析2003年北京市1291例SARS患者(其中121例死亡)的病例资料,比较既往有心脑血管基础疾病和有、无其他基础疾病三组SARS患者病死率的差异及死亡危险因素。结果SARS患者总的病死率为937%。既往有心脑血管疾病、其他基础病和无基础病的SARS患者病死率分别为2864%、1185%和449%(P<00001)。Logistic回归分析表明,调整年龄和职业后既往有心脑血管病的SARS患者死亡的相对危险是无基础病患者的183倍(P<005)。结论既往有心脑血管基础疾病是SARS患者死亡的重要危险因素之一。

Influence of underlying cerebrocardiovascular diseases on mortality of patients with severe acute respiratory syndrome

Objective To investigate the influance of underlying cerebrocardiovascular diseases on mortality of patients with severe acute respiratory syndrome (SARS). Methods 1291 cases, including 121 death cases, with complete hospital records from the Beijing Clinical Database of SARS Patients in the year 2003 were analyzed. The mortality of SARS patients was compared among groups with underlying cerebrocardiovascular diseases, other comorbid diseases and absence of comorbid diseases. Results The total mortality of SARS cases was 9 37%. The mortality of SARS patients with underlying cerebrocardiovascular diseases, other comorbid diseases and absence of comorbid diseases were 28 64%, 11 85% and 4 49%, respectively ( P <0 0001). The Logistic regression analysis showed that the presence of cerebrocardiovascular diseases in SARS patients would bring about a significantly higher risk of death (Odds Ratio, OR ]=1 83, 95% CI =1 07 3 14), after adjusting for possible confounding factors such as age and occupation. Conclusion Cerebrocardiovascular diseases are important risk factors of death in SARS cases.