文拉法辛与氟西汀对抑郁症的疗效及对认知功能的改善作用研究

目的：研究文拉法辛与氟西汀对抑郁症的疗效及对认知功能的改善作用。方法回顾性分析2012年1月-2014年1月来我院应用文拉法辛治疗的32例抑郁症患者的临床资料，设为观察组，另选择同期应用氟西汀治疗的32例抑郁症患者的临床资料，设为对照组，比较两组的疗效及两组患者治疗前后HAMD评分、认知功能。结果观察组治疗后的总有效率达93.75%，显著高于对照组（P〈0.05）。观察组与对照组患者的HAMD评分分别较治疗前显著降低，且观察组患者的HAMD评分显著低于对照组（P〈0.05）。观察组和对照组患者治疗8周后的WCST总数、持续错误数、随机错误数显著少于治疗前，且显著少于对照组（P〈0.05）。对照组患者治疗8周后正确数、持续错误数均较治疗前未见明显变化，差异无显著性（P〉0.05）。结论文拉法辛治疗抑郁症的疗效及对认知功能的改善作用较氟西汀更具优势。

Effect of venlafaxine and fluoxetine in depression and improvement on cognitive function

Objective To study the effect of venlafaxine and fluoxetine in depression and improvement on cognitive function. Methods Retrospectively analyzed from January 2012 to January 2014 in our hospital for treatment of 32 cas-es of depression with venlafaxine in patients with clinical data, set up for the observation group, selected the same pe-riod of fluoxetine in 32 patients with depression in patients with clinical data, set up as the control group, HAMD score, cognitive function before and after treatment were compared between two groups. Results The total effective rate of ob-servation group after treatment was 93.75%,was significantly higher than the control group （P〈0.05）. The observation group and the control group of patients with HAMD scores were significantly lower than before treatment, and the HAMD score of observation group was significantly lower than that of the control group （P〈0.05）. The observation group group after treatment 8 weeks, number of errors, random errors were significantly lower than before treatment, and sig-nificantly less than the control group （P〈0.05）. Patients in the control group after 8 weeks of treatment, number of perse-verative errors connected rates had no significant difference before treatment （P〉0.05）. Conclusion Venlafaxine in the treatment of depression and improve the effect on cognitive function, has more advantages than fluoxetine.