前列地尔联合甲钴胺治疗糖尿病周围神经病变的临床研究

目的探讨前列地尔联合甲钴胺治疗糖尿病周围神经病变的疗效。方法选择糖尿病周围神经病变患者80例,对照组予甲钴胺,治疗组同时联合前列地尔,连用4周。比较两组的疗效及神经传导速度的变化情况。结果治疗组与对照组的总有效率比较,差异有统计学意义（92.5%vs 70.0%,χ^2=6.348,P〈0.05）。两组患者治疗后的腓总神经、正中神经的MCV、SCV与治疗前比较明显提高,且治疗组患者治疗后的腓总神经、正中神经MCV、SCV与对照组治疗后比较改善更显著（P〈0.05）。结论糖尿病周围神经病变的治疗除常规降糖治疗外辅助前列地尔联合甲钴胺治疗的疗效确切,二者具有协同作用,可以明显提高疗效。

Clinical research of alprostadil combined mecobalamin in threatment of diabetic peripheral neuropathy

Objective To investigate effect of alprostadil combined mecobalamin in threatment of diabetic peripheral neuropathy. Methods A total of 80 cases diabetic peripheral neuropathy patients were selected, the control group was given mecobalamin,treatment group added alprostadil four weeks. The efficacy nerve conduction velocity were compared. Results The total effective rate of the treatment group and the control group was 92.5%,70.0%（χ^2=6.348,P〈0.05）. Peroneal nerve in the treactment group and control group patients after treatment of the common peroneal nerve,median nerve MCV,former SCV comparison with significantly improved treatment and observation of patients after treatment, the median nerve MCV,SCV after treatment with the control group（P〈0.05）. Conclusion Alprostadil combined mecobalamin diabetic peripheral neuropathy has exact effect,with a synergistic effect, worthy of promotion and application.