肿瘤免疫治疗PD-1/PD-L1靶向核素分子探针的研究进展

Bone and soft tissue tumor is a rare disease and its incidence is low. There are few studies on this kind of tumors in the world every year. Based on the research of bone and soft tissue tumor in recent years, this paper reviews the core contents of osteosarcoma, Ewing’s sarcoma, soft tissue sarcoma, sarcomas followup, targeted therapy and immunotherapy. At the same time, we analyze the unsolved problems and put forward the solutions and suggestions to provide references for clinicians in this field. © 2020, CHINA RESEARCH ON PREVENTION AND TREATMENT. All rights reserved.

Research Progress of PD-1/PD-L1 Targeted Radionuclide Molecular Probes in Tumor Immunotherapy

PD-1/PD-L1 immune checkpoint therapy has become another important treatment for several refractory and recurrent tumors besides radiotherapy and chemotherapy;however,only some patients can benefit from it.PD-1/PD-L1 targeted radionuclide molecular probe imaging can detect the PD-1/PD-L1 expression in whole body including tumors and other tissues noninvasively,timely and repeatedly,which will be more convenient for screening the patients benefiting from the immune-therapy,the efficacy evaluation and dynamic monitoring of the changes of PD-1/PD-L1 expression during treatment,providing a strong basis for the adjustment of treatment plan.This paper will review the recent progress of PD-1/PD-L1 targeted molecular probes,in order to provide reference for clinical application and further research of tumor immunotherapy.