| 三七总皂苷鼻腔用制剂的研究 |
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| 引用本文： | 许清芳,方晓玲,陈道峰,李珺婵.三七总皂苷鼻腔用制剂的研究[J].药学学报,2003,38(11):859-862. |
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| 作者姓名： | 许清芳 方晓玲 陈道峰 李珺婵 |
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| 作者单位： | 1. 复旦大学,药学院,药剂教研室,上海,200032
2. 复旦大学,药学院,生药教研室,上海,200032 |
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| 摘 要： | 目的研究能够提高三七总皂苷生物利用度的给药途径和制剂。方法采用鼻腔给药筛选提高药物生物利用度的适宜制剂。结果本试验中制备的制剂在不引起黏膜刺激性的条件下，大幅度提高了PNS的生物利用度。结论可从给药途径和剂型两方面考虑提高药物吸收，降低刺激性。
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| 关 键 词： | 三七总皂苷 鼻黏膜给药 生物利用度 喷雾制剂 |
| 收稿时间： | 2002-11-18 |
Studies on formulations of Panax notoginsenosides for intranasal administration |
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| XU Qing-fang,FANG Xiao-ling,CHEN Dao-feng LI Jun-chan.Studies on formulations of Panax notoginsenosides for intranasal administration[J].Acta Pharmaceutica Sinica,2003,38(11):859-862. |
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| Authors: | XU Qing-fang FANG Xiao-ling CHEN Dao-feng LI Jun-chan |
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| Affiliation: | Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China. |
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| Abstract: | AIM: To develop high bioavailability preparations without irritation for Panax notoginsenosides. METHODS: The effects of some additives such as microcrystalline cellulose, beta-cyclodextrin and hydroxypropyl cellulose on drug in the preparations were examined. RESULTS: Saponins of Panax notoginseng (PNS) was absorbed in rabbits more when administered intranasally than through other routines, and the formulations including MCC both gave high bioavailability and low irritation. CONCLUSION: Bioavailability of Panax notoginsenosides can be increased through changing routine of administration and formulations. |
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| Keywords: | Panax notoginsenosides intranasal administration bioavailability spray formulations |
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