TIP30与VEGF-C 在乳腺癌中的表达及意义

目的]检测转录反式作用因子结合蛋白(TIP30)与血管内皮生长因子-C(VEGF-C)在乳腺癌中的表达水平。方法]应用免疫组织化学Elivision法,检测72例乳腺癌及其癌旁乳腺组织中TIP30和VEGF-C蛋白表达水平,并分析它们与临床病理指标之间的关系。结果]TIP30蛋白在乳腺癌及相应的癌旁乳腺组织中的阳性表达率分别是33.33%、87.50%,两者之间差异有显著性(P<0.05)。VEGF-C蛋白在乳腺癌及相应的癌旁乳腺组织中的阳性表达率分别是80.56%、26.39%,两者之间差异有显著性(P<0.05)。TIP30蛋白、VEGF-C蛋白在乳腺癌的表达与有无淋巴结转移有关(P<0.05),而与患者年龄、临床分期、肿瘤大小、c-erbB-2和雌、孕激素受体表达均无关(P>0.05)。结论]TIP30在乳腺癌旁组织中的表达明显高于癌组织,VEGF-C表达情况则相反,两者呈负相关。

Expressions of TIP30 and VEGF-C in Breast Cancer and Their Significance

Purpose ] To investigate the expressions of Tat-interacting protein 30 （TIP30） and vas- cular endothelial growth factor-C（VEGF-C） in breast cancer. Methods] The expressions of TIP30 and VEGF-C in sample tissues from 72 cases with breast cancer and corresponding adjacent breast tissues were detected with Elivision immunohistochemical method, and their relationship with clinicopathologic parameters was analyzed. Results] The positive expression of TIP30 in breast cancer tissues and adjacent breast tissues were 33.33% and 87.50% respectively,with sig- nificant difference between them （P〈0.05）. The positive expression of VEGF-C in breast cancer tissues and adjacent breast tissues were 80.56% and 26.39% respectively, with significant differe- nce between them （P〈0.05）. The expressions of TIP30 and VEGF-C in breast cancer correlated to lymph node metastasis with or without（P〈0.05）, but had not correlate to age, stage, tumor size, c- erbB-2, ER and PR （P〉0.05）. Conclusion ~ The expression of TIP30 in adjacent breast tissues is higher than that in breast cancer tissues, with a reverse expression of VEGF-C. There is a nega- tive correlation between the expression of TIP30 and VEGF-C in breast cancer.